추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
제품 라인
Prestige Antibodies® Powered by Atlas Antibodies
양식
buffered aqueous glycerol solution
종 반응성
mouse, rat, human
기술
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
면역원 서열
KEGKSNEKNDFTKFKTEQENEAKCRNSKPGKKKNDFEQGELYLREKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLL
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... LACTB(114294)
일반 설명
Lactamase beta (LACTB) is a 60kDa mammalian mitochondrial protein. The protein shows sequence similarity to sequence β-lactamases and penicillin binding proteins (PBPs), which occurs in bacteria. It is expressed in skeletal muscle, heart and liver. The gene is located on human chromosome 15q22.2.
면역원
lactamase, beta recombinant protein epitope signature tag (PrEST)
애플리케이션
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
생화학적/생리학적 작용
Lactamase beta (LACTB) inhibits the proliferation of breast cancer cells, by modifying the mitochondrial lipid metabolism and differentiation of breast cancer cells. It contributes to intra-mitochondrial membrane organization, modulates complex I of the mitochondrial electron transport chain and controls cellular metabolic processes. This protein might act as a therapeutic target for gliomas. It may function as a tumor suppressor gene.
특징 및 장점
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
결합
Corresponding Antigen APREST78751
물리적 형태
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
법적 정보
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
가장 최신 버전 중 하나를 선택하세요:
Overexpression of LACTB, a Mitochondrial Protein, that Inhibits Proliferation and Invasion in Glioma Cells.
Li HT, et al.
Oncology Research, 335-342 (2017)
Expression and purification of the mitochondrial serine protease LACTB as an N-terminal GST fusion protein in Escherichia coli
Liobikas J, et al.
Protein Expression and Purification, 45(2), 335-342 (2006)
LACTB-mediated tumour suppression by increased mitochondrial lipid metabolism
Cucchi D and Mauro C
Cell Death and Differentiation, 24, 335-342 (2017)
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample.
Loukola A
Molecular Psychiatry, 19(5), 615-624 (2014)
LACTB is a tumour suppressor that modulates lipid metabolism and cell state
Keckesova Z, et al.
Nature, 543(7647), 681-681 (2017)
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