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Merck
모든 사진(5)

주요 문서

HPA029590

Sigma-Aldrich

Anti-SLC11A1 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

동의어(들):

Anti-Lsh, Anti-Nramp, Anti-Nramp1, Anti-Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

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About This Item

UNSPSC 코드:
12352203
인간 단백질 도해서 번호:
NACRES:
NA.41
결합:
unconjugated
application:
IHC
클론:
polyclonal
종 반응성:
human
citations:
7
기술:
immunohistochemistry: 1:50- 1:200

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

제품 라인

Prestige Antibodies® Powered by Atlas Antibodies

양식

buffered aqueous glycerol solution

종 반응성

human

기술

immunohistochemistry: 1:50- 1:200

면역원 서열

TSPGPQQAPPRETYLSEKIPIPDTKPGTFSLR

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... SLC11A1(6556)

일반 설명

Solute carrier family 11 member 1 (SLC11A1) is a multi-pass membrane protein. It is expressed in macrophages and neutrophils. The gene is located on human chromosome 2q35.

면역원

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 recombinant protein epitope signature tag (PrEST)

애플리케이션

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

생화학적/생리학적 작용

Solute carrier family 11 member 1 (SLC11A1) helps in transporting divalent metal ions (Mn2+ and Fe2+) and iron metabolism. It contributes to host innate immune response against infections. The protein regulates CXC chemokine KC, interleukin-1b (IL-1b), inducible nitric oxide synthase (iNOS), major histocompatibility complex (MHC) class II molecules, tumor necrosis factor α (TNFα), nitric oxide (NO) release, L-arginine flux, oxidative burst, tumoricidal and antimicrobial activity. The protein plays an important role in disease pathology and susceptibility. Mutations in this gene is linked to rheumatoid arthritis, tuberculosis and inflammatory bowel disease.

특징 및 장점

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

결합

Corresponding Antigen APREST78903

물리적 형태

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

법적 정보

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake
Mulero V, et al.
The Biochemical Journal, 363(1), 89-94 (2002)
Genomewide linkage analysis of the granulomatous mitsuda reaction implicates chromosomal regions 2q35 and 17q21
Ranque B, et al.
The Journal of Infectious Diseases, 196(8), 1248-1252 (2007)
Twenty-four signature genes predict the prognosis of oral squamous cell carcinoma with high accuracy and repeatability
Gao J, et al.
Molecular Medicine Reports, 17(2), 2982-2990 (2018)
Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: systematic review and meta-analysis
Archer NS, et al.
Genes and Immunity, 16(4), 275-275 (2015)
Identification of single nucleotide polymorphisms in the bovine solute carrier family 11 member 1 (SLC11A1) gene and their association with infection by Mycobacterium avium subspecies paratuberculosis
Ruiz-Larranaga O, et al.
Journal of Dairy Science, 93(4), 1713-1721 (2010)

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