추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
제품 라인
Prestige Antibodies® Powered by Atlas Antibodies
형태
buffered aqueous glycerol solution
종 반응성
human
향상된 검증
independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
기술
immunohistochemistry: 1:200- 1:500
면역원 서열
KTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKW
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... DSC2(1824)
일반 설명
Desmocollin 2 (DSC2) is a type I membrane glycoprotein that is localized in the cardiac tissue and other desmosome-containing tissues. It is expressed as two different splice variants with different carboxy-termini. DSC2a isoform possesses a larger cytoplasmic domain than the DSC2b isoform. The gene encoding this protein is present on chromosome 18. DSC2 contains four extracellular amino terminal domains, that is, an extracellular anchor domain (EA), a short transmembrane domain (TM), an intracellular anchor domain (IA), and an intracellular cadherin-binding domain (ICS). It has a single transmembrane domain and a cytoplasmic tail at the carboxy terminus.
면역원
Desmocollin-2 precursor recombinant protein epitope signature tag (PrEST)
애플리케이션
Anti-DSC2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige. Anti-DSC2 antibody produced in rabbit can also be used for immunoprecipitation.
생화학적/생리학적 작용
Desmocollin 2 (DSC2) homo- and heterodimerize with each other and links the neighbouring cells by the interactions with the help of their extracellular cadherin domains. The domains also help these proteins to bind to desmogleins in a Ca2+-dependent manner. Its intracellular portions interact with plakoglobin (PG) and plakophilin-2 (PKP2). These two proteins in turn bind to desmoplakin (DSP) and provide a link to intermediate filaments. Mutations in the gene encoding DSC2 lead to arrhythmogenic right ventricular cardiomyopathy. DSC2 is essential for the establishment of early cardiac morphogenesis, normal myocardial structure and function and desmosome formation.
특징 및 장점
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
결합
Corresponding Antigen APREST72496
물리적 형태
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
법적 정보
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2.
P Syriss
American Journal of Human Genetics, 79(5), 978-984 (2006)
Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
B Gerull et. al.
Circulation. Cardiovascular Genetics, 6(4), 327-336 (2013)
Brenda Gerull et al.
Circulation. Cardiovascular genetics, 6(4), 327-336 (2013-07-19)
Dominant mutations in cellular junction proteins are the major cause of arrhythmogenic cardiomyopathy, whereas recessive mutations in those proteins cause cardiocutaneous syndromes such as Naxos and Carvajal syndrome. The Hutterites are distinct genetic isolates who settled in North America in
Arnd Heuser et al.
American journal of human genetics, 79(6), 1081-1088 (2006-12-23)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically heterogeneous heart-muscle disorder characterized by progressive fibrofatty replacement of right ventricular myocardium and an increased risk of sudden cardiac death. Mutations in desmosomal proteins that cause ARVC have been previously described; therefore
Katja Gehmlich et al.
Cardiovascular research, 90(1), 77-87 (2010-11-11)
Recent immunohistochemical studies observed the loss of plakoglobin (PG) from the intercalated disc (ID) as a hallmark of arrhythmogenic right ventricular cardiomyopathy (ARVC), suggesting a final common pathway for this disease. However, the underlying molecular processes are poorly understood. We
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