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HPA001897

Sigma-Aldrich

Anti-ILF3 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

동의어(들):

Anti-DRBP76 antibody produced in rabbit, Anti-Double-stranded RNA-binding protein 76 antibody produced in rabbit, Anti-Interleukin enhancer-binding factor 3 antibody produced in rabbit, Anti-NF-AT-90 antibody produced in rabbit, Anti-NFAR antibody produced in rabbit, Anti-Nuclear factor associated with dsRNA antibody produced in rabbit, Anti-Nuclear factor of activated T-cells 90 kDa antibody produced in rabbit, Anti-TCP80 antibody produced in rabbit, Anti-Translational control protein 80 antibody produced in rabbit

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모든 사진(6)

About This Item

UNSPSC 코드:
12352203
인간 단백질 도해서 번호:
HPA001897
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

제품 라인

Prestige Antibodies® Powered by Atlas Antibodies

형태

buffered aqueous glycerol solution

종 반응성

human

기술

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:2500-1:5000

면역원 서열

VMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIK

UniProt 수납 번호

Q12906

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ILF3(3609)

관련 카테고리

일반 설명

ILF3 (interleukin enhancer binding factor 3) is a double-stranded nuclear RNA-binding protein. It is composed of a bipartite nuclear localization signal (NLS), an RGG (Arg-Gly-Gly) box RNA-binding motif, and two double-stranded RNA binding domains (dsRBDs) that acts as novel nuclear export sequence (NES) in intact cells.

면역원

Interleukin enhancer-binding factor 3 recombinant protein epitope signature tag (PrEST)

애플리케이션

Anti-ILF3 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

생화학적/생리학적 작용

Exportin-5 mediates the transport of ILF3 (interleukin enhancer binding factor 3) from nucleus to cytoplasm. VA1 RNA, exportin-5, ILF3 and RanGTP forms a quaternary complex, which mediates the interaction between ILF3 and exportin-5. Later, ILF3 affinity towards VA1 is stimulated by exportin-5 that facilitates the interaction between RNA and the export receptor. These events cause co-export of both VA1 and ILF3.

특징 및 장점

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

결합

Corresponding Antigen APREST86210

물리적 형태

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

법적 정보

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Matthias Habjan et al.
PLoS pathogens, 9(10), e1003663-e1003663 (2013-10-08)
Viruses that generate capped RNA lacking 2'O methylation on the first ribose are severely affected by the antiviral activity of Type I interferons. We used proteome-wide affinity purification coupled to mass spectrometry to identify human and mouse proteins specifically binding
Carole Gwizdek et al.
The Journal of biological chemistry, 279(2), 884-891 (2003-10-23)
The karyopherin-related nuclear transport factor exportin-5 preferentially recognizes and transports RNAs containing minihelix motif, a structural cis-acting export element that comprises a double-stranded stem (>14 nucleotides) with a base-paired 5' end and a 3-8-nucleotide protruding 3' end. This structural motif
Amy M Brownawell et al.
The Journal of cell biology, 156(1), 53-64 (2002-01-05)
We have identified a novel human karyopherin (Kap) beta family member that is related to human Crm1 and the Saccharomyces cerevisiae protein, Msn5p/Kap142p. Like other known transport receptors, this Kap binds specifically to RanGTP, interacts with nucleoporins, and shuttles between
Yü Liu et al.
Molecular medicine reports, 20(1), 125-134 (2019-05-23)
Interleukin enhancer‑binding factor 3 (ILF3) may function as a transcriptional coactivator and has been reported to be involved in tumor proliferation and metastasis; however, its role and clinical value in gastric cancer (GC) remains unclear. To understand the value of
Adriana Forero et al.
Virology, 458-459, 4-10 (2014-06-15)
Primary effusion lymphoma (PEL), associated with the latent infection by KSHV, constitutively expresses interferon-regulatory factor 4 (IRF4). We recently showed that IRF4 differentially regulates expression of cellular interferon-stimulated genes (ISGs) and viral genes (Forero et al., 2013). Here, using inducible
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