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Merck
모든 사진(1)

Key Documents

H7791

Sigma-Aldrich

IL-17A human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

동의어(들):

CTLA-8, IL-17

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.77

product name

Interleukin-17A human, IL-17A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

생물학적 소스

human

Quality Level

재조합

expressed in HEK 293 cells

분석

≥95% (SDS-PAGE)

형태

lyophilized powder

효능

≤2 ng/mL EC50

품질

endotoxin tested

분자량

dimer 30-35 kDa (glycosylated)

포장

pkg of 10 μg

기술

cell culture | mammalian: suitable

불순물

≤1 EU/μg

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... IL17A(3605)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
IL-17A belongs to the IL-17 family and is produced by Th17 cells, a subset of T helper cells. Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. IL-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines, upregulates production of growth factors that promote angiogenesis, and enhances expression of adhesion molecules in fibroblasts.

물리적 형태

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl pH 7.4+ 250 mM NaCl

제조 메모

HumanKine Interleukin-17A (IL-17A), expressed in human HEK 293 cells, is a glycosylated homodimer with an apparent molecular mass of 30-35 kDa due to glycosylation. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

분석 메모

The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF adult fibroblasts.

법적 정보

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Shu Zhu et al.
The Journal of experimental medicine, 207(12), 2647-2662 (2010-11-17)
Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this
Stéphane Dragon et al.
American journal of respiratory cell and molecular biology, 50(6), 1053-1063 (2014-01-08)
Airway smooth muscle (ASM) cells are thought to contribute to the pathogenesis of allergic asthma by orchestrating and perpetuating airway inflammation and remodeling responses. In this study, we evaluated the IL-17RA signal transduction and gene expression profile in ASM cells
H Xiong et al.
International endodontic journal, 48(6), 505-511 (2014-07-22)
To investigate IL-17 expression in human pulpitis and to study the effects of IL-17 on the secretion of the chemokines IL-6 and IL-8 and the related signalling pathways. Samples of human dental pulp tissue were obtained from healthy controls and
Junhua Wang et al.
PLoS neglected tropical diseases, 9(5), e0003755-e0003755 (2015-05-09)
The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. We previously showed that Fibrinogen-like-protein 2 (FGL2), a novel CD4+CD25+ Treg effector molecule, was over-expressed
Michael Notaras et al.
Molecular psychiatry (2021-06-24)
It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may increase risk of neuropsychiatric illness in offspring. However, little progress has been made in defining human-specific in utero neurodevelopmental

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