H7789

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-H1 Histone family, member 4, Anti-H1.4K26ac, Anti-H1K26ac, Anti-H1e, Anti-Histone 1, Anti-Histone H1b
• MDL number: MFCD09753843
• UNSPSC 코드: 12352203

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~35 kDa
• 종 반응성: human
• 기술: western blot: 0.5-1 μg/mL using acid-extracted fraction of HL60 cells
• UniProt 수납 번호: P10412
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: acetylation (Lys26)
• 유전자 정보: human ... HIST1H1E(3008)

설명

일반 설명

In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain.

면역원

synthetic acetylated peptide corresponding to amino acids 22-33 (Ac-Lys²⁶) of human histone H1.4.

애플리케이션

Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit is suitable for western blot at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells.

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

H1.4 at lysine residue 26 represses transcription. Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. Histone modifications are thought to play an important role in cancer and disease.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)