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Key Documents

H2504

Sigma-Aldrich

His-Leu

≥98% (TLC), suitable for ligand binding assays

동의어(들):

histidylleucine

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About This Item

실험식(Hill 표기법):
C12H20N4O3
CAS Number:
Molecular Weight:
268.31
MDL number:
UNSPSC 코드:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

His-Leu,

분석

≥98% (TLC)

Quality Level

형태

solid

기술

ligand binding assay: suitable

색상

white to off-white

저장 온도

−20°C

SMILES string

CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O

InChI

1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

InChI key

MMFKFJORZBJVNF-UHFFFAOYSA-N

생화학적/생리학적 작용

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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R A Santos et al.
Hypertension (Dallas, Tex. : 1979), 7(2), 244-252 (1985-03-01)
The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu. Our results indicate that, in contrast to human serum, rat serum and plasma contain large and variable amounts of dipeptidase activity
J B Vita et al.
Investigative ophthalmology & visual science, 20(2), 255-257 (1981-02-01)
Angiotensin II is a biological active octapeptide that is formed by the action of angiotensin-converting enzyme (ACE) on the inactive precursor, angiotensin I. ACE activity was found in tears and aqueous humor from both rabbit and human eyes. The activity
V Schusdziarra et al.
Peptides, 7(1), 127-133 (1986-01-01)
Bombesin-like immunoreactivity (BLI) has been demonstrated in neurons of the gastrointestinal tract and gastric BLI secretion can be demonstrated in response to the classical neurotransmitter acetylcholine. Since structurally related peptides VIP, PHI and GRF have to be considered as peptidergic
K Iwatsuki et al.
Clinical and experimental pharmacology & physiology, 20(7-8), 501-507 (1993-07-01)
1. The effects of peptide histidine isoleucine (PHI) on pancreatic exocrine secretion were investigated in preparations of the isolated and blood-perfused dog pancreas as compared with those of vasoactive intestinal peptide (VIP), secretin and glucagon. 2. Each peptide tested was
S Ceccatelli et al.
Neuroendocrinology, 49(3), 309-323 (1989-03-01)
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the

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