H0786

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• 동의어(들): HRG-β
• MDL number: MFCD01867052
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥80% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 분자량: 185 kDa
• 포장: pkg of 100 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• UniProt 수납 번호: Q02297
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... NRG1(3084)

설명

일반 설명

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

생화학적/생리학적 작용

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

물리적 형태

Solution in phosphate buffered saline containing 30% glycerol.

분석 메모

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable