H0417

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

• 동의어(들): HCF2, HCII, SERPIND1
• CAS Number: 81604-65-1
• MDL number: MFCD00285907
• UNSPSC 코드: 12352202
• NACRES: NA.61

속성

• 생물학적 소스: human plasma
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 양식: aqueous glycerol solution
• 분자량: ~66 kDa; ~66 kDa
• NCBI 수납 번호: NP_000176
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... SERPIND1(3053)

설명

생화학적/생리학적 작용

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.

Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

단위 정의

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

물리적 형태

50% aqueous glycerol solution (vol/vol)

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable