추천 제품
생물학적 소스
human
Quality Level
분석
97-100% (agarose gel electrophoresis)
양식
lyophilized powder
기술
immunofluorescence: suitable
적합성
suitable for electrophoresis and chromatography standard
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... HBA2(3040)
일반 설명
Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).
애플리케이션
Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.
생화학적/생리학적 작용
Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.
포장
Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).
재구성
When reconstituted with buffer, gives >90% ferrous hemoglobin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Determination of HbA2 by quantitative bottom-up proteomics and isotope dilution mass spectrometry
Arsene C, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 487, 318-324 (2018)
Burçin Nalbantoğlu et al.
Pediatric hematology and oncology, 29(5), 472-478 (2012-08-08)
Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the
Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies
Loucari C, et al.
Human Gene Therapy Methods, 29(1), 60-74 (2018)
Saqib Hussain Ansari et al.
JPMA. The Journal of the Pakistan Medical Association, 62(12), 1314-1317 (2013-07-23)
To screen immediate family members of thalassaemia patients for carrier identification and counselling. The cross-sectional study was conducted at an urban thalassaemia treatment and prevention centre in Karachi, Pakistan, from January to December 2008, and involved 188 siblings of 100
Haemoglobin A₂ analysis.
A D Stephens
International journal of laboratory hematology, 35(1), 116-116 (2012-11-20)
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