추천 제품
생물학적 소스
chicken
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human
제조업체/상표
Genway 15-288-21255B
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... XPOT(11260)
일반 설명
XPOT (exportin T) is a tRNA nuclear export receptor found in vertebrates. This protein shuttles between the cytoplasm and nucleus. It belongs to the importin-β family, and has a distant relation to Los1p protein found in yeast.
애플리케이션
Anti-Exportin T antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
생화학적/생리학적 작용
Exportin-T acts as a specific mediator of tRNA export. Exportin-T is a RanGTP-binding, importin β-related factor with predominantly nuclear localization that shuttles rapidly between nucleus and cytoplasm. It interacts with nuclear pore complexes as well. Exportin-t binds tRNA directly and with high affinity. It is responsible for majority of tRNA export in cells and plays an essential role in the transport of tRNA. It is associated with intracellular tRNA trafficking and is in turn associated with discrete changes in the composition of cellular cytoplasmic multi-protein complexes containing tRNA.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.
Takuji Suzuki et al.
Biomedical research (Tokyo, Japan), 27(2), 89-92 (2006-05-19)
The active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (DVD), is a potent inducer of cell differentiation and inhibits proliferation of cells such as human promyelocytic leukemia HL-60 cells. In the present study, we examined the effects of DVD on the
C Kruse et al.
The Biochemical journal, 346 Pt 1, 107-115 (2000-02-05)
Vigilin is a ubiquitous multi heterogeneous nuclear ribonucleoprotein (hnRNP) K homologous (KH)-domain protein. Here we demonstrate that purified recombinant human vigilin binds tRNA molecules with high affinity, although with limited specificity. Nuclear microinjection experiments revealed for the first time that
U Kutay et al.
Molecular cell, 1(3), 359-369 (1998-07-14)
In eukaryotes, tRNAs are synthesized in the nucleus and after several maturation steps exported to the cytoplasm. Here, we identify exportin-t as a specific mediator of tRNA export. It is a RanGTP-binding, importin beta-related factor with predominantly nuclear localization. It
G J Arts et al.
The EMBO journal, 17(24), 7430-7441 (1998-12-19)
Exportin-t (Xpo-t) is a vertebrate nuclear export receptor for tRNAs that binds tRNA cooperatively with GTP-loaded Ran. Xpo-t antibodies are shown to efficiently block tRNA export from Xenopus oocyte nuclei suggesting that it is responsible for at least the majority
G J Arts et al.
Current biology : CB, 8(6), 305-314 (1998-03-25)
Transport of macromolecules between the nucleus and cytoplasm of eukaryotic cells is mediated by nuclear import and export receptors. The receptors identified to date are members of a family of Ran GTPase-binding proteins whose founding member is importin-beta. Interaction between
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