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Merck
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Key Documents

GW20087F

Sigma-Aldrich

Anti-Human Kappa Light Chain antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-Immunoglobulin kappa

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

chicken

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

종 반응성

human

제조업체/상표

Genway 15-288-20087F

기술

western blot: suitable

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... IGKC(3514)

면역원

Human IgK (Kappa) native protein.

애플리케이션

Anti-Human Kappa Light Chain antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

생화학적/생리학적 작용

Immunoglobulin κ constant (IGKC) is a human gene that encodes the constant domain of κ-type light chains for antibodies. It is found on chromosome 2 in humans. IGKC acts as a strong prognostic marker in several human solid tumors, including breast cancer. Its expression may have a role for humoral immunity in breast cancer progression. IGKC is also found to be expressed in non-small lung cancer (NSCLC) and may act as a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response. Its has an independent protective impact on disease-free survival (DFS) and breast cancer-specific overall survival in node-negative breast cancer. IGKC acts as a novel diagnostic marker for risk stratification in human cancer and may help to exploit the humoral immune response for anticancer therapy.

물리적 형태

Solution in phosphate buffered saline containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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문서 라이브러리 방문

Janardan P Pandey et al.
Immunobiology, 219(2), 113-117 (2013-09-24)
Immunoglobulin κ constant (IGKC) gene has recently been identified as a strong prognostic marker in several human solid tumors, including breast cancer. Although the mechanisms underlying the IGKC signature are not yet known, identification of tumor-infiltrating plasma cells as the
Zonglin Chen et al.
PloS one, 7(9), e44741-e44741 (2012-10-03)
Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. IGKC expression was
Miriam Lohr et al.
Cancer letters, 333(2), 222-228 (2013-02-02)
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray.
Marcus Schmidt et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(9), 2695-2703 (2012-02-22)
Although the central role of the immune system for tumor prognosis is generally accepted, a single robust marker is not yet available. On the basis of receiver operating characteristic analyses, robust markers were identified from a 60-gene B cell-derived metagene
Torben Knuschke et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(8), 1787-1798 (2014-07-12)
Retroviral infections e.g. HIV still represent a unique burden in the field of vaccine research. A common challenge in vaccine design is to find formulations that create appropriate immune responses to protect against and/or control the given pathogen. Nanoparticles have

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