G11100P

DMT-dG(ib) Pharmadite^®

• 동의어(들): DMT-dG(ib) Phosphoramidite, N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• 실험식(Hill 표기법): C₄₄H₅₄N₇O₈P
• CAS Number: 93183-15-4
• Molecular Weight: 839.92
• MDL number: MFCD00055147
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329799722

속성

• 생물학적 소스: non-animal source (no BSE/TSE risk)
• Quality Level: 300
• 유형: for DNA synthesis
• 제품 라인: Proligo Reagents
• 분석: ≥99.5% (reversed phase HPLC); >99.5% (³¹P-NMR)
• 형태: powder or granules
• 기술: oligo synthesis: suitable
• 불순물: >= 170ppm, none detected (S/N <2.5); ≤0.1% P(III) 100-169ppm (³¹P-NMR); ≤0.1% single unspecified Imprity (reversed phase HPLC); ≤0.3% dG2 (reversed phase HPLC, DMT-dG(ib) cyanoethyl-H-posphonate); ≤0.3% dG3 (reversed phase HPLC, DMT-dG(ib) phosphoramidate); ≤0.3% dG4 (reversed phase HPLC, DMT-dG(ib)-diisopropylamino-H-phosphonate); ≤0.30 wt. % water content (Karl Fischer); ≤0.5% P(V) -25-99ppm (³¹P-NMR); ≤3.0 wt. % residual solvent content
• 색상: white to off-white
• solubility: soluble, clear
• 적합성: conforms to structure for H-NMR; conforms to structure for LC-MS
• 뉴클레오시드 프로파일: base: deoxyguanosine; base protecting group: isobutyryl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• 저장 온도: 2-8°C
• SMILES string: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
• InChI: 1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1
• InChI key: FDRMKYVTIFSDPR-MMROLVBFSA-N

설명

일반 설명

DMT-dG(ib) Pharmadite^® is a Pharmadite^® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity. Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free from contaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remaining impurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

법적 정보

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable