G0278

Galanin human

≥97% (HPLC), powder

• 실험식(Hill 표기법): C₁₃₉H₂₁₀N₄₂O₄₃
• CAS Number: 119418-04-1
• Molecular Weight: 3157.41
• MDL number: MFCD00135986
• UNSPSC 코드: 12352209
• PubChem Substance ID: 329799804
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 구성: Peptide content, ≥70%
• UniProt 수납 번호: P22466
• 저장 온도: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@@H]4CCCN4C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc5ccc(O)cc5)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc6c[nH]c7ccccc67)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O
• InChI: 1S/C139H210N42O43/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-/m0/s1
• InChI key: CBSXZYWGVAQSHI-RUKUCZSXSA-N
• 유전자 정보: human ... GAL(51083)

설명

Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser

일반 설명

Galanin (GAL) is a neuropeptide composed of 29 amino acids. It has wide range of expression in central and peripheral nervous system. It acts as a ligand for three G-protein coupled receptor (GPCR) subtypes called GalR1, GalR2 and GalR3.

애플리케이션

Galanin human has been used in immunohistochemistry performed on ileums of pigs to study the effect of the mycotoxin zearalenone on the expression of intestinal peptides.

생화학적/생리학적 작용

Galanin (GAL) is involved in multiple physiological actions such as, nociception, cognition, memory, hunger, hormone and neurotransmitter release, and cell growth. It also controls the release of gastric acid, plays a role in the contraction of intestines, and suppresses the secretion of pancreatic peptides. This peptide is up-regulated in colorectal cancer (CRC), which relates to aggressive phenotype and poor prognosis of patients with stage II CRC. Studies in Chinese Han female population show that polymorphisms in this gene are linked to susceptibility to depression.

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)