분석
≥98% (HPLC)
형태
solid
색상
white
solubility
DMSO: ~24 mg/mL (with warming up to 60 °C)
H2O: insoluble
저장 온도
2-8°C
SMILES string
Clc1ccc(cc1)N2CCN(CC2)Cc3cc4ccccn4n3
InChI
1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2
InChI key
DTRXURJDKOYCCD-UHFFFAOYSA-N
유전자 정보
human ... DRD2(1813) , DRD3(1814) , DRD4(1815)
애플리케이션
FAUC 213 has been used as a selective dopamine receptor D4-R antagonist:
- to test its effect on the expression of luteinizing hormone in eel pituitary primary cell culture
- to test its effect on bupropion induced hypophagia and locomotion in rats
- to test its modulatory effects on rat basolateral amygdala in the presence of dopamine
생화학적/생리학적 작용
FAUC 213 displays antipsychotic properties and may be of use in studies related to behavioral neurobiology and neurochemistry.
Highly selective D4 dopamine receptor full antagonist
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
S Löber et al.
Journal of medicinal chemistry, 44(17), 2691-2694 (2001-08-10)
Structure dependent efficacy studies in the field of selective D4 ligands led to the 2-aminomethyl substituted azaindole 2 (FAUC 213) that displayed strong D4 binding, high subtype selectivity, and complete antagonist properties in ligand-induced mitogenesis experiments. According to our schematic
Frank Boeckler et al.
Psychopharmacology, 175(1), 7-17 (2004-03-10)
2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213) is a highly selective antagonist at the dopamine D(4) receptor subtype. It was designed as a derivative of two partial antagonists and has been proven to be a complete antagonist in mitogenesis assay. In the present study
Blocking alpha2A adrenoceptors, but not dopamine receptors, augments bupropion-induced hypophagia in rats.
Janhunen, et al.
Obesity (Silver Spring, Md.), 21, E700-E708 (2017)
Hironori Ohshiro et al.
Neuropharmacology, 61(4), 857-866 (2011-06-21)
The amygdala receives dopaminergic innervation, and dopamine (DA) enhances various activities in cognitive and emotional behaviors. Periodic bursts of spontaneous inhibitory postsynaptic currents (IPSCs) with a low (<1 Hz) inter-event frequency have been observed in projection neurons of the basolateral
C Jolly et al.
Journal of neuroendocrinology, 28(9) (2016-07-28)
In various vertebrate species, dopamine (DA) exerts an inhibitory action on reproduction. In the European eel, DA plays a pivotal role in the inhibitory control of gonadotroph function and the blockade of puberty. In vivo studies have suggested that this
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