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Merck
모든 사진(1)

주요 문서

F0504

Sigma-Aldrich

Folate binding protein from bovine milk

lyophilized powder

동의어(들):

Folate Protein

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.61

생물학적 소스

bovine milk

Quality Level

양식

lyophilized powder

사용

 mg sufficient for ~4,000 assays

구성

Protein, 20-40% modified Warburg-Christian

기술

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

용량

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

저장 온도

−20°C

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애플리케이션

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

생화학적/생리학적 작용

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

포장

Package size based on protein content

품질

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

물리적 형태

Lyophilized powder containing buffer salt as sodium citrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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이미 열람한 고객

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Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)

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