추천 제품
![[(BENZHYDRYLOXY)(PHENYL)METHYL]BENZENE AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/848/247/6351af74-e74c-4949-a644-d112b75e7677/640/6351af74-e74c-4949-a644-d112b75e7677.png)
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
white
solubility
DMSO: >10 mg/mL
H2O: insoluble
저장 온도
room temp
SMILES string
CC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
InChI
1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
InChI key
MJJALKDDGIKVBE-UHFFFAOYSA-N
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일반 설명
Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.
애플리케이션
Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.
생화학적/생리학적 작용
Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.
Ebastine is a non-sedating histamine H1 receptor antagonist.
특징 및 장점
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata.
Manabu Ohyama et al.
Journal of dermatological science, 58(2), 154-157 (2010-04-15)
Yoshiaki Kitamura et al.
Acta oto-laryngologica, 132(4), 434-438 (2012-01-06)
These findings suggest that the down-regulation of interleukin (IL)-5 gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines
Daniel Aguilar et al.
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), 56(2), 36-40 (2009-06-17)
Allergic rhinitis is an inflammatory disease of the nasal mucosa, with common symptoms, which is essentially characterized by nasal itching, nasal congestion, sneezing, hyaline rhinorrhea and repetitive sneezing. The disease is very common, 15% of the population worldwide suffers it.
N V Tsiskarishvili et al.
Georgian medical news, (167)(167), 52-56 (2009-03-12)
The clinical efficacy of antihistaminic preparation "Kestine" (Ebastine) in combined treatment of 50 patients suffering from photo-allergic dermatosis (15 - solar urticaria, 20 - solar erythema and 15 - solar eczema) are evaluated. Kestine in dosage of 10 mg a
Young Hyo Kim et al.
American journal of rhinology & allergy, 24(4), e89-e92 (2010-09-08)
Many researchers have focused on the definition and pathophysiology of localized mucosal allergy. However, there are few studies on its clinical characteristics and therapeutic outcomes. The goal of this study was to analyze the prevalence, epidemiology, clinical characteristics, and response
문서
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