E3539

Proteinase 3 from human leukocytes

≥95% (PAGE)

• 동의어(들): AGP7, Myeloblastin, P29B, PR-3, PR3 Ag
• 효소 위원회 번호: 3.4.21.76 (BRENDA, IUBMB)
• MDL number: MFCD03458212
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 분석: ≥95% (PAGE)
• 양식: buffered aqueous solution
• UniProt 수납 번호: P24158
• 저장 온도: −20°C
• 유전자 정보: human ... PRTN3(5657)

설명

일반 설명

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.⁴

애플리케이션

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.¹ It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.²

생화학적/생리학적 작용

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.³

Used for the detection of anti-PR3 auto-antibodies in immunoassays.

물리적 형태

Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable