추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen ~80 kDa
종 반응성
human, rat
기술
immunohistochemistry: 20-40 μg/mL
immunoprecipitation (IP): 0.5-1 μg using RIPA extract of human A431 cells
indirect immunofluorescence: 10-20 μg/mL
western blot (chemiluminescent): 0.5-1 μg/mL using whole extract of rat NRK cells
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... EZR(7430)
mouse ... Ezr(22350)
rat ... Ezr(54319)
관련 카테고리
일반 설명
Ezrin is a 80kDa membrane-associated protein that belongs to ERM (Ezrin/Radixin/Moesin) family. Ezrin is found predominantly in polarized epithelial cells such as intestinal epithelial cells, gastric parietal cells, epithelial cells of the kidney proximal tubule, terminal bronchiole of the lung, and in mesothelia.
면역원
synthetic peptide corresponding to amino acids 479-498 of human ezrin with N-terminal added cysteine, conjugated to KLH. The corresponding sequence in rat and mouse differs by three amino acids.
애플리케이션
Anti-Ezrin antibody produced in rabbit has been used in:
- immunolocalization studies
- immunostaining
- immunofluorescence and immunohistochemistry
- immunoblot
생화학적/생리학적 작용
Cultured neuronal cells do express ezrin to some extent, and whole brain tissue expresses low levels of ezrin. Ezrin expression is associated with malignancy in astrocytoma, osteosarcoma, mammary and pancreatic adenocarcinomas, and in cutaneous and uveal melanomas.
Ezrin promotes cell adhesion. The NH2-terminal domain negatively regulates membrane spreading and elongation properties of ezrin COOH-terminal domain. The members of ERM family are usually involved in cross-linking of plasma membrane and actin filaments. ERM proteins are involved in cell adhesion, cell shape determination, migration, and the organization of cell surface structures. They are also involved in signal transduction and apoptosis. Ezrin has been implicated in tumor progression and metastatic spread.
물리적 형태
Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Vijay B Arumugham et al.
Frontiers in immunology, 9, 919-919 (2018-05-17)
A central feature of the immune synapse (IS) is the tight compartmentalization of membrane receptors and signaling mediators that is functional for its ability to coordinate T cell activation. Second messengers centrally implicated in this process, such as Ca2+ and
AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway
Morishita M, et al.
International journal of oncology, 50(1), 23-30 (2017)
Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma
Xie YH, et al.
The International Journal of Biochemistry & Cell Biology, 112(19), 79-87 (2019)
Suvi Ilmonen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(4), 503-510 (2004-10-12)
Ezrin is a member of the ezrin-radixin-moesin family of proteins that link the actin-containing cytoskeleton to the plasma membrane. Ezrin is also connected to signaling molecules involved in the regulation of cell survival, proliferation and migration. Here, we examined the
A Bretscher
Current opinion in cell biology, 11(1), 109-116 (1999-02-27)
Molecules involved in ERM (ezrin-radixin-moesin) based attachment of membrane proteins to the cortical cytoskeleton in cell surface structures have been identified. In lymphocytes, a direct interaction is seen with extracellular matrix receptors and intercellular adhesion molecules. In polarized epithelial cells
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