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Merck
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주요 문서

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E1279

Sigma-Aldrich

Enoximone

solid

동의어(들):

1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C12H12N2O2S
CAS Number:
77671-31-9
Molecular Weight:
248.30
MDL number:
MFCD00867130
UNSPSC 코드:
41106305
PubChem Substance ID:
24278408
NACRES:
NA.77

양식

solid

색상

light yellow

solubility

DMSO: soluble 28 mg/mL

SMILES string

CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2

InChI

1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)

InChI key

ZJKNESGOIKRXQY-UHFFFAOYSA-N

유전자 정보

human ... PDE3A(5139) , PDE3B(5140)

생화학적/생리학적 작용

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE.
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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시험 성적서(COA)

Lot/Batch Number
074M4622V
075K4610
042K4601

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문서 라이브러리 방문

S Schauvliege et al.
Equine veterinary journal, 41(8), 778-785 (2010-01-26)
No studies have been reported on the effects of enoximone in anaesthetised colic horses. To examine whether enoximone improves cardiovascular function and reduces dobutamine requirement in anaesthetised colic horses. Forty-eight mature colic horses were enrolled in this prospective, randomised clinical
H J Gilfrich et al.
Zeitschrift fur Kardiologie, 80 Suppl 4, 93-97 (1991-01-01)
Enoximone, a new phosphodiesterase-inhibitor with positive inotropic and vasodilating activities is available for intravenous use in patients with severe heart failure. A review of the current knowledge regarding the adverse effects of this substance reveals that they are characterized by
B Hausen et al.
European heart journal, 13(5), 679-686 (1992-05-01)
Inotropic support is often required for post-operative management of patients following mitral valve operation. The use of positive inotropes is limited by tolerance development and increase in myocardial oxygen demand. We have compared i.v. enoximone (E) (group E, n =
Paolo Nardi et al.
The Annals of thoracic surgery, 87(5), 1401-1407 (2009-04-22)
Coronary artery bypass grafting (CABG) is a well-accepted therapeutic strategy for patients with multivessel coronary artery disease and left ventricular dysfunction. The aim of the study was to evaluate long-term results after CABG in patients with preoperative left ventricular ejection
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 36(3), 197-208 (2009-04-29)
To compare cardiac output () measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Prospective randomized experimental cross-over trial. Six ponies aged 5.0 +/- 1.6 (4-6.5)
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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