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Merck
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Key Documents

D9442

Sigma-Aldrich

Anti-Dopamine Transporter, Extracellular Loop 2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

동의어(들):

Anti-DAT

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous glycerol solution

종 반응성

monkey, human

기술

immunohistochemistry: 1:1,000 using formaldehyde-fixed human and monkey brain sections
western blot: 1:1,000 using SDS-solubilized human striatal samples

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... SLC6A3(6531)

면역원

synthetic peptide from the extracellular loop 2 region of human dopamine transporter.

애플리케이션

Anti-Dopamine Transporter, Extracellular Loop 2 antibody produced in rabbit is suitable at a working dilution of 1:1000 for western blotting using SDS-solubilized human striatal samples and for immunohistochemistry using formaldehyde-fixed human and monkey brain sections.

생화학적/생리학적 작용

The dopamine transporter (DAT1) acts to take released dopamine back up into presynaptic terminals and has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse. DAT1 gene is a primary target gene for ADHD (Attention deficit hyperactivity disorder). DAT polymorphism along with maternal prenatal smoking is associated with childhood hyperactivity-impulsivity and inattentiveness.

표적 설명

The dopamine transporter (DAT1) acts to take released dopamine back up into presynaptic terminals and has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse.

물리적 형태

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Robert S Kahn et al.
The Journal of pediatrics, 143(1), 104-110 (2003-08-14)
To examine the joint effects of a dopamine transporter (DAT) polymorphism and maternal prenatal smoking on childhood hyperactivity-impulsivity and inattentiveness. A cohort of 161 children was followed prospectively from age 6 months to 60 months. Primary outcomes were the DSM-IV
I D Waldman et al.
American journal of human genetics, 63(6), 1767-1776 (1998-12-05)
Attention-deficit hyperactivity disorder (ADHD) affects approximately 3%-5% of children in the United States. In the current psychiatric nomenclature, ADHD comprises three subtypes: inattentive, hyperactive-impulsive, and combined. In this study, we used four analytic strategies to examine the association and linkage

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