D5446

7,8-Dihydroxyflavone hydrate

≥98% (HPLC)

• 실험식(Hill 표기법): C₁₅H₁₀O₄ · xH₂O
• CAS Number: 38183-03-8
• Molecular Weight: 254.24 (anhydrous basis)
• EC Number: 253-812-4
• MDL number: MFCD00006836
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329798806
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• solubility: DMSO: 24 mg/mL
• 저장 온도: room temp
• SMILES string: Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
• InChI: 1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
• InChI key: COCYGNDCWFKTMF-UHFFFAOYSA-N

설명

애플리케이션

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

생화학적/생리학적 작용

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.

7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable