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Merck
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D2191

Sigma-Aldrich

Monoclonal Anti-DC-SIGN1 antibody produced in mouse

clone 120507, purified immunoglobulin, lyophilized powder

동의어(들):

Anti-CD209, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin

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모든 사진(1)

About This Item

MDL number:
MFCD03701938
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

200

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

120507, monoclonal

양식

lyophilized powder

종 반응성

human

기술

flow cytometry: 2.5 μg using 106 cells
immunocytochemistry: 8-25 μg/mL
immunohistochemistry: 8-25 μg/mL using fixed cells and tissue sections
western blot: 1 μg/mL

동형

IgG2b

UniProt 수납 번호

Q9NNX6

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... CD209(30835)

일반 설명

DC-SIGN is a type II protein C-type lectin that binds mannose-rich molecules such as ICAM-3 and ICAM-2 in a calcium dependent manner. DC-SIGN, a 44 kDa molecule, is identical to the HIV-1 binding protein.

특이성

Recognizes human DC-SIGN on transfected cells and on monocyte derived dentritic cells. The antibody does not react with either parental mouse cells or irrelevant transfectants, such as human DC-SIGN2.

면역원

purified from NIH/3T3 cells transfected with recombinant human DC-SIGN.

애플리케이션

Monoclonal Anti-DC-SIGN1 antibody produced in mouse is suitable for flow cytometry, immunocytochemistry at a working concentration of 8-25 μg/mL, immunohistochemistry at 8-25 μg/mL using fixed cells and tissue sections and western blotting at 1 μg/mL.

생화학적/생리학적 작용

DC-SIGN1 is involved in molecular interactions between dendritic cells and resting T-cells. DC-SIGN interacts with viruses such as X4, R5, X4R5 HIV-1 strains, HIV-2, and SIV. It captures HIV-1 through its interaction with the gp120 envelope glycoprotein and promotes efficient infection of CD4+ T cells that co-express chemokine receptors.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLBZ8464
SLBX5788
SLBV5966
SLBT0488
SLBH9795V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리 방문

S Pöhlmann et al.
Journal of virology, 75(10), 4664-4672 (2001-04-20)
Dendritic cells (DCs) efficiently bind and transmit human immunodeficiency virus (HIV) to cocultured T cells and so may play an important role in HIV transmission. DC-SIGN, a novel C-type lectin that is expressed in DCs, has recently been shown to
T B Geijtenbeek et al.
Cell, 100(5), 575-585 (2000-03-18)
Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is important in this first contact with DC. We discovered that instead of
T B Geijtenbeek et al.
Cell, 100(5), 587-597 (2000-03-18)
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of
T B Geijtenbeek et al.
Nature immunology, 1(4), 353-357 (2001-03-23)
Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign antigens. After antigen uptake and processing, DCs migrate to the secondary lymphoid organs to initiate immune responses. We now show that DC-SIGN, a DC-specific C-type lectin, supports
B M Curtis et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(17), 8356-8360 (1992-09-01)
The binding of the human immunodeficiency virus (HIV) envelope glycoprotein gp120 to the cell surface receptor CD4 has been considered a primary determinant of viral tropism. A number of cell types, however, can be infected by the virus, or bind
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