D1819

Anti-DYRK1A (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MNB protein kinase, Anti-MNB/MNBH, Anti-Minibrain Drosophila homolog
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~86 kDa
• 종 반응성: mouse, human, rat
• 농도: ~1 mg/mL
• 기술: western blot: 1-2 μg/mL using rat brain embryonic extract; western blot: 2-4 μg/mL using rat brain postnatal extract
• UniProt 수납 번호: Q13627
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... DYRK1A(1859) ; mouse ... Dyrk1a(13548) ; rat ... Dyrk1a(25255)

설명

일반 설명

Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), also known as minibrain/Mnb is a member of a growing family of Ser/Thr protein kinases termed dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). DYRKs also possess autophosphorylation activity on tyrosine residues, located on the YXY motif of the activation loop of the catalytic domain.

The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.

애플리케이션

Anti-DYRK1A (C-terminal) antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.

DYRK1A phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves