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Merck
모든 사진(1)

Key Documents

D034

Sigma-Aldrich

(−)-Butaclamol hydrochloride

solid

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About This Item

실험식(Hill 표기법):
C25H31NO · HCl
CAS Number:
Molecular Weight:
397.98
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

형태

solid

광학 활성

[α]27/D −222° in methanol(lit.)

색상

white

solubility

H2O: 0.25 mg/mL
ethanol: 1 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.4 mg/mL
alcohol-water mixtures: soluble (Dissolve solid in alcohol and dilute with water.)

SMILES string

Cl[H].[H][C@]12C[C@](O)(CCN1C[C@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C

InChI

1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m1./s1

InChI key

QZRUMKUMFJJARD-OMMJFLKZSA-N

생화학적/생리학적 작용

Dopamine receptor antagonist; less active enantiomer.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

Rajamani Selvam et al.
Synapse (New York, N.Y.), e22075-e22075 (2018-10-20)
Brain-derived neurotrophic factor (BDNF), traditionally known for promoting neuronal growth and development, is also a modulator of synaptic transmission. In addition to the well-characterized effects at excitatory synapses, BDNF has been shown to acutely suppress inhibitory neurotransmission; however, the underlying
Effect of butaclamol and its enantiomers upon striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.
W Lippmann et al.
Life sciences, 16(2), 213-224 (1975-01-15)
T A Pugsley et al.
The Journal of pharmacy and pharmacology, 29(3), 135-138 (1977-03-01)
Butaclamol (1.0-0.1 mg kg-1, i.p.) and spiroperidol (1-0-0-5 mg kg-1, i.p.) but not (-)-butaclamol (15 mg kg-1, i.p.), blocked the hyperactivity induced in rats by tranylcypromine-L-tryptophan pretreatment. Neither butaclamol nor spiroperidol altered the accumulation of brain 5-HT following parglyine or
T A Pugsley et al.
Canadian journal of physiology and pharmacology, 54(4), 510-515 (1976-08-01)
The 3-isopropyl (I), 3-cyclohexyl (II) and 3-phenyl (III) analogs of the new antipsychotic drug butaclamol, which contains a 3-tertiary butyl group, and their respective (+)-enantiomers, but not (-)-enantiomers, caused a dose related elevation of rat striatal homovanillic acid concentration, indicative

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