추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen ~19 kDa
종 반응성
human
기술
western blot: 1:500-1:2,000
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CIRBP(1153)
일반 설명
CIRBP is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures.
면역원
synthetic peptide corresponding to amino acids 121-135 of human CIRBP
애플리케이션
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CIRBP antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000.
생화학적/생리학적 작용
Extracellular CIRBP is a detrimental factor in stimulating inflammation to cause neuronal damage in cerebral ischemia. It may have a protective effect on testicular injury after testicular torsion/detorsion when upregulated. Downregulation of CIRBP has been shown to increase germ cell apoptosis.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Zhiping Xia et al.
Journal of pediatric surgery, 48(10), 2140-2147 (2013-10-08)
To evaluate the expression of Cold-inducible RNA-binding protein (CIRP) in torsion/detorsion of the testes in different phases and demonstrate the protective effect of CIRP on testicular injury after torsion/detorsion (T/D) in an experimental mouse model. Twenty-four male BALB/c mice were
Zhi-Ping Xia et al.
Asian journal of andrology, 14(6), 884-889 (2012-09-25)
Cold-inducible RNA-binding protein (CIRP) is an RNA-binding protein that is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures. The purpose of this study was to investigate the functions of CIRP in the
Wen Hao Ren et al.
Medical oncology (Northwood, London, England), 31(8), 120-120 (2014-07-17)
Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the
Mian Zhou et al.
Biochimica et biophysica acta, 1840(7), 2253-2261 (2014-03-13)
Neuroinflammation is a key cascade after cerebral ischemia. Excessive production of proinflammatory mediators in ischemia exacerbates brain injury. Cold-inducible RNA-binding protein (CIRP) is a newly discovered proinflammatory mediator that can be released into the circulation during hemorrhage or septic shock.
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