생물학적 소스
mouse
Quality Level
재조합
expressed in NS.1 cells
분석
≥99% (SDS-PAGE)
형태
buffered aqueous solution
분자량
97 kDa
포장
pkg of 1 mg
저장 조건
avoid repeated freeze/thaw cycles
불순물
≤1 EU/mg protein Endotoxin level (LAL test)
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
mouse ... Cd152(12477) , Ctla4(12477)
일반 설명
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
생화학적/생리학적 작용
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
기타 정보
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
물리적 형태
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
제조 메모
Purified from serum-free tissue culture supernatant
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Amod A Sarnaik et al.
Cancer journal (Sudbury, Mass.), 15(3), 169-173 (2009-06-27)
Metastatic melanoma is a disease associated with poor prognosis, with a median survival reported to range from 6 to 9 months. Patients who are not candidates for surgical resection have an even worse expected survival. This is largely due to
W Steurer et al.
Journal of immunology (Baltimore, Md. : 1950), 155(3), 1165-1174 (1995-08-01)
To test the hypothesis that blockade of B7-triggered costimulation by donor cells could preclude allograft rejection, we coated crude islet allograft preparations in vitro for 1 h with a murine CTLA4/Fc fusion protein. Murine CTLA4/Fc blocks the proliferative response in
Andrew L Mellor et al.
International immunology, 16(10), 1391-1401 (2004-09-08)
Murine dendritic cells (DCs) expressing indoleamine 2,3 dioxygenase (IDO) catabolize tryptophan and can suppress T cell responses elicited in vivo. Here, we identify specific subsets of splenic (CD11c+) dendritic cells competent to mediate IDO-dependent T cell suppression following CTLA4-mediated ligation
Andrew L Mellor et al.
Journal of immunology (Baltimore, Md. : 1950), 171(4), 1652-1655 (2003-08-07)
In mice, immunoregulatory APCs express the dendritic cell (DC) marker CD11c, and one or more distinctive markers (CD8alpha, B220, DX5). In this study, we show that expression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced in specific
P S Linsley et al.
The Journal of experimental medicine, 174(3), 561-569 (1991-09-01)
Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 counter-receptor on activated B lymphocytes, and subsequently to costimulate interleukin 2 production
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