추천 제품
생물학적 소스
bovine coronary artery (USDA-inspected cattle)
Quality Level
포장
pkg of 500,000 cells
제조업체/상표
Cell Applications, Inc
성장 모드
Adherent
핵형
2n = 60
형태학
Endothelial
기술
cell culture | mammalian: suitable
관련 질환(들)
cardiovascular diseases
저장 온도
−196°C
일반 설명
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BCAEC have been used to demonstrate that the stress hormone cortisol inhibits NO synthase and Ca2+ mobilization leading to decreased NO release by endothelial cells, resulting in increased arterial contraction and decreased blood flow (Rogers, 2002). Similar action mechanism were determined for cocaine effects on arteries (He, 2005). Additionally it was found that cocaine-induced apoptosis of endothelial cells is mediated by attenuation of NO production, down-regulation of Bcl-2 and translocation of Bac to the mitochondria, followed by release of cytochrome c and activation of caspase 9 and caspase 3 (He, 2000, 2001). BCAEC were also used to determine that diabetes-related vascular dysfunction is mediated by decreased NO production due to direct substrate competition between NO synthase and arginase whose activity is markedly increased in many conditions characterized by vascular dysfunction (Romero, 2008). BCAEC were also used to evaluate novel mesh-like materials for their suitability for biomedical applications (Nair, 2004).
BCAEC have been used to demonstrate that the stress hormone cortisol inhibits NO synthase and Ca2+ mobilization leading to decreased NO release by endothelial cells, resulting in increased arterial contraction and decreased blood flow (Rogers, 2002). Similar action mechanism were determined for cocaine effects on arteries (He, 2005). Additionally it was found that cocaine-induced apoptosis of endothelial cells is mediated by attenuation of NO production, down-regulation of Bcl-2 and translocation of Bac to the mitochondria, followed by release of cytochrome c and activation of caspase 9 and caspase 3 (He, 2000, 2001). BCAEC were also used to determine that diabetes-related vascular dysfunction is mediated by decreased NO production due to direct substrate competition between NO synthase and arginase whose activity is markedly increased in many conditions characterized by vascular dysfunction (Romero, 2008). BCAEC were also used to evaluate novel mesh-like materials for their suitability for biomedical applications (Nair, 2004).
세포주 기원
Artery
애플리케이션
cardiovascular function, angiogenesis, vascular biology, regulation of coronary blood flow, cardiac functions, effects of vaso-dilators, coagulation, fibrinolysis, vessel wall tone, cytokine production
성분
Bovine Endothelial Cell Growth Medium containing 10% FBS & 10% DMSO
제조 메모
- 3rd passage, >500,000 cells in Bovine Endothelial Cell Growth Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 16 doublings
계대배양 정규 작업
Please refer to the BCAEC Culture Protocol.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
프로토콜
Technical information for working with bovine brain microvascular endothelial cells including thawing, subculturing and cryopreservation
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