A7730

A-331440 dihydrochloride

≥98% (HPLC), solid

• 동의어(들): 4’-[3-[(3(R)-Dimethylamino-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4‘-carbonitrile dihydrochloride
• 실험식(Hill 표기법): C₂₂H₂₇N₃O · 2HCl
• CAS Number: 392338-13-5
• Molecular Weight: 422.39
• MDL number: MFCD08705336
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724398
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: H₂O: ≥10 mg/mL
• 주관자: Abbott
• 저장 온도: 2-8°C
• SMILES string: CN([C@H]1CN(CCCOC2=CC=C(C3=CC=C(C#N)C=C3)C=C2)CC1)C.[H]Cl.[H]Cl
• InChI: 1S/C22H27N3O.2ClH/c1-24(2)21-12-14-25(17-21)13-3-15-26-22-10-8-20(9-11-22)19-6-4-18(16-23)5-7-19;;/h4-11,21H,3,12-15,17H2,1-2H3;2*1H/t21-;;/m1../s1
• InChI key: XFPYVTSGYYMTFS-GHVWMZMZSA-N

설명

생화학적/생리학적 작용

A-331440 dihydrochloride is a non-imidazole H₃ histamine receptor antagonist.

A-331440 dihydrochloride is a non-imidazole H₃ histamine receptor antagonist. Presynaptic histamine H(3) receptors regulate release of histamine and other neurotransmitters, and histamine H(3) receptor antagonists enhance neurotransmitter release. A-331440 is a histamine H(3) receptor antagonist, which binds potently and selectively to both human and rat histamine H(3) receptors (K(i)=25 nM). Mice on a high-fat diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-fat diet. The two higher doses reduced body fat and the highest dose also normalized an insulin tolerance test. Both data shows that the histamine H(3) receptor antagonist, A-331440, has potential as an antiobesity agent.

특징 및 장점

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)