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Merck
모든 사진(1)

주요 문서

A6608

Sigma-Aldrich

Albumin human

recombinant, expressed in Saccharomyces cerevisiae, aqueous solution, 10% in aqueous buffer, ≥99% (agarose gel electrophoresis)

동의어(들):

rHSA

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About This Item

실험식(Hill 표기법):
C2936H4624N786O889S41
CAS Number:
Molecular Weight:
66471.53
MDL number:
UNSPSC 코드:
12352202
eCl@ss:
42010201
NACRES:
NA.25

생물학적 소스

human

Quality Level

재조합

expressed in Saccharomyces cerevisiae

분석

≥99% (agarose gel electrophoresis)

양식

aqueous solution

분자량

monomer ~67 kDa

농도

10% in aqueous buffer

기술

cell culture | mammalian: suitable

UniProt 수납 번호

저장 온도

2-8°C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

유전자 정보

human ... ALB(213)

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일반 설명

Albumin constitutes 25% of the proteins produced by the liver and is a prominent protein found in the blood. It is a protein of a single polypeptide chain with a thiol group.

애플리케이션

Albumin human has been used:
  • to study its adsorption process on model mica surface at pH 3.5 using the atomic force microscopy (AFM) and in situ streaming potential measurements
  • to study its proteolytic activities under reducing conditions
  • in the medium for stem cell cultivation

This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.

생화학적/생리학적 작용

Albumin is a binding and transport protein that serves as a protein repository and a carrier for amino acids. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This also prevents the loss of substance through excretion. Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia. This product can be used in the pharmaceutical industry as a drug excipient and to coat medical devices.
Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.

분석 메모

Endotoxin tested

기타 정보

View more information on human serum albumin.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

N A Pham et al.
Cytometry, 41(4), 245-251 (2000-11-21)
Increased mitochondrial generation of reactive oxygen intermediates (ROI) due to defective respiratory chain activity has been implicated in physiological processes such as apoptosis, in the pathogenesis of mitochondrial diseases, and as part of the normal aging process. Established methods addressing
Veronica Liv Andersen et al.
Theranostics, 9(9), 2662-2677 (2019-05-28)
Rationale: Within the field of personalized medicine there is an increasing focus on designing flexible, multifunctional drug delivery systems that combine high efficacy with minimal side effects, by tailoring treatment to the individual. Methods: We synthesized a chemically stabilized ~4
Dmitry Kryndushkin et al.
Pharmaceutical research, 34(4), 765-779 (2017-02-06)
Protein carbonylation is an irreversible modification of Lys, Arg, Thr and Pro amino acids under conditions of oxidative stress. Previous studies have reported specific carbonylated residues in purified recombinant albumins, albeit with a lack of agreement between the studies. Currently
Dmitry Kryndushkin et al.
Pharmaceutical research, 33(2), 526-539 (2015-10-27)
Ascorbic acid has been considered as a potential radical scavenging excipient for pharmaceutical formulations. However, under certain circumstances, ascorbic acid can generate reactive oxygen species via redox cycling. The objective of this study was to investigate ascorbic acid-induced oxidative carbonylation
Felix Manstein et al.
Methods in molecular biology (Clifton, N.J.), 1994, 79-91 (2019-05-28)
This chapter describes a detailed protocol on human pluripotent stem cells (hPSCs) cultivation as matrix-free cell-only aggregates in defined and xeno-free culture medium in stirred tank bioreactors (STBRs). Starting with a frozen stock pre-expanded on conventional culture dishes (2D), the

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