A5236

Anti-ASF1 antibody, Mouse monoclonal

clone 4A1/3, purified from hybridoma cell culture

• 동의어(들): Anti-ASF1A, Anti-Silencing function 1 homolog A
• UNSPSC 코드: 12352203
• NACRES: NA.43

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: purified from hybridoma cell culture
• 항체 생산 유형: primary antibodies
• 클론: 4A1/3, monoclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~23 kDa
• 종 반응성: mouse, human
• 농도: ~1.0 mg/mL
• 기술: western blot: 2-4 μg/mL using whole extract of human Jurkat or Raji cells
• 동형: IgG2a
• UniProt 수납 번호: Q9Y294
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ASF1A(25842)

설명

일반 설명

ASF1 is a histone chaperone protein that binds H3 and H4. It functions in nucleosome assembly.

Monoclonal Anti-ASF1 (mouse IgG2a isotype) is derived from the hybridoma 4A1/3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with an ASF1A fusion protein. ASF1 (anti-silencing function 1) encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast.

면역원

ASF1A fusion protein

애플리케이션

Monoclonal Anti-ASF1 antibody produced in mouse has been used in immunoblotting.

생화학적/생리학적 작용

ASF1 (anti-silencing function 1) protein is a key component of a histone donor complex. It interacts with histones H3 and H4 and functions together with a chromatin assembly factor 1 (CAF-1) during DNA replication and repair. ASF1 also contributes to genome stability during S phase. Cells lacking ASF1 were found to be sensitive to a number of genotoxic agents that predominantly cause DNA damage by interfering with DNA replication fork progression such as hydroxyurea and camptothecin.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable