추천 제품
분석
≥95.0% (GC)
양식
powder or crystals
불순물
≤6.0% water
저장 온도
2-8°C
2-8°C
SMILES string
[Na+].[Na+].OC(CCC([O-])=O)C([O-])=O
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2
InChI key
DZHFTEDSQFPDPP-UHFFFAOYSA-L
생화학적/생리학적 작용
D-(or R-) enantiomer of α-hydroxyglutaric acid is a cancer related biomarker of diagnostic value, whereas the L-(or S-) enantiomer of α-hydroxyglutaric acid is a biomarker for certain neurometabolic, inherited disorder diseases. It has no known physiological function in eukaryotes. It is toxic to the brain and increases the susceptibility to develop brain tumors.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Cancer: A metabolic metamorphosis.
Abigail S Krall et al.
Nature, 496(7443), 38-40 (2013-04-05)
Jelena Lazovic et al.
Neuro-oncology, 14(12), 1465-1472 (2012-10-24)
The arginine 132 (R132) mutation of isocitrate dehydrogenase -1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients. The majority of lower-grade gliomas express IDH1(R132), whereas this mutation
Progress in understanding 2-hydroxyglutaric acidurias
Martijn Kranendijk
Journal of inherited metabolic disease, 35(4), 571-587 (2012)
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
K E Yen
Oncogene (2010)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang
Nature (2009)
프로토콜
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
Chromatograms
application for HPLCapplication for HPLC자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.