92283

Polymyxin B solution

20 mg/mL in H₂O

• 동의어(들): Aerosporin, Polymyxin B, Polymyxin B Sulfate
• CAS Number: 1405-20-5
• MDL number: MFCD00131991
• UNSPSC 코드: 51283106
• NACRES: NA.85

속성

• 생물학적 소스: Bacillus polymyxa (fermentation)
• 형태: liquid
• 광학 활성: [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
• 농도: 20 mg/mL in H₂O
• 색상: colorless to slightly yellow
• solubility: H₂O: soluble 20 mg/mL
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; fungi
• 동작 모드: cell membrane | interferes
• 저장 온도: 2-8°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI key: HNDFYNOVSOOGDU-UHFFFAOYSA-N

설명

일반 설명

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa.

애플리케이션

Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

생화학적/생리학적 작용

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.

Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.

포장

10ml, 125ml

제조 메모

This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves