콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

487R-9

SMAD4 (MRQ-72) Rabbit Monoclonal Antibody

동의어(들):

Mothers Against Decapentaplegic Homolog 4 Rabbit Monoclonal Antibody

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

UNSPSC 코드:
12352203

생물학적 소스

rabbit

Quality Level

500

항체 생산 유형

primary antibodies

클론

MRQ-72, monoclonal

설명

For In Vitro Diagnostic Use in Select Regions

포장

vial of 0.1 mL concentrate (487R-94)
vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only
vial of 0.5 mL concentrate (487R-(95)
vial of 1.0 mL (concentrate (487R-96))
vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only
vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only
vial of 1.0 mL pre-dilute ready-to-use (487R-97)
vial of 7.0 mL pre-dilute ready-to-use (487R-98)
vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only

제조업체/상표

Cell Marque™

동형

IgG

제어

pancreas

시각화

cytoplasmic, nuclear

일반 설명

Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon. However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.

품질

IVD - MQ500

RUO - MQ100

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

Download the IFU specific to your product lot and format

Note: This requires a keycode which can be found on your packaging or product label.

기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

법적 정보

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

적합한 제품을 찾을 수 없으신가요?  

당사의 제품 선택기 도구.을(를) 시도해 보세요.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

죄송합니다. 지금은 이 제품에 대한 COA이(가) 온라인에서 제공되지 않습니다.

도움이 필요하시면 연락하세요. 고객 지원 부서

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Michael Torbenson et al.
Human pathology, 33(9), 871-876 (2002-10-16)
In the normal liver, the transforming growth factor beta (TGF-beta) signaling pathway plays an important role in inhibiting hepatocyte growth. This effect is mediated through Smad4 (or Dpc4), a tumor-suppressor gene that affects gene transcription and controls cell growth. A
R Salovaara et al.
Gut, 51(1), 56-59 (2002-06-22)
Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a
Y H Kim et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 15(4), 574-580 (2004-03-23)
Transforming growth factor-beta (TGF-beta) modulates the growth and function of many cells, including those with malignant transformation. Smad proteins have been identified as major components in the intracellular signaling of TGF-beta family members. To clarify the correlations between clinicopathologic profiles

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.