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Merck
모든 사진(3)

주요 문서

483R-1

Sigma-Aldrich

p40 (ZR8) Rabbit Monoclonal Antibody

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About This Item

UNSPSC 코드:
12352203
클론:
ZR8
application:
IHC (p)
종 반응성:
human
기술:
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))
citations:
8

생물학적 소스

rabbit

Quality Level

100
500

결합

unconjugated

항체 형태

culture supernatant

항체 생산 유형

primary antibodies

클론

ZR8

설명

For In Vitro Diagnostic Use in Select Regions

양식

buffered aqueous solution

종 반응성

human

포장

vial of 0.1 mL concentrate (483R-14)
vial of 0.1 mL concentrate, Research Use Only (483R-14-RUO)
vial of 0.5 mL concentrate (483R-15)
vial of 1.0 mL concentrate (483R-16)
vial of 1.0 mL concentrate, Research Use Only (483R-16-RUO)
vial of 1.0 mL pre-dilute, Research Use Only (483R-17-RUO)
vial of 1.0 mL pre-dilute, ready to use (483R-17)
vial of 25.0 mL pre-dilute, ready-to-use (483R-10)
vial of 25.0 mL pre-dilute, ready-to-use, Research Use Only (483R-10-RUO)
vial of 7.0 mL pre-dilute, ready to use (483R-18)
vial of 7.0 mL pre-dilute, ready to use, Research Use Only (483R-18-RUO)

제조업체/상표

Cell Marque

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

동형

IgG

제어

lung (squamous cell carcinoma), prostate, urothelial carcinoma

배송 상태

wet ice

저장 온도

2-8°C

시각화

nuclear

관련 카테고리

일반 설명

p40 is an isoform of p63, a transcription factor that regulates many cell activities, including cell proliferation, maintenance, and differentiation. It performs as a sensitive and specific tool for aiding in the identification of squamous cell carcinoma of the lung. In addition to its utility as a squamous differentiation marker, p40 has also been proven to be a valuable marker for highlighting myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland.1-5 Strong p40 expression is frequently observed in esophageal cancerous squamous lesions.6 Immunohistochemical detection of p40 can also be helpful in identifying urothelial carcinoma.7 In cases of prostate carcinoma, p40 is almost always found to be negative for basal cell staining.8

품질

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Hermann Brustmann
Pathology research international, 2015, 897927-897927 (2015-04-09)
Immunohistochemistry is important for the accurate diagnosis of basal cells in atypical glandular proliferations of the prostate. p40, an isoform of p63, may be an adjunct to a marker panel in this setting. Biopsies of 68 patients were analyzed by
Khairunisa Ahmad Affandi et al.
Journal of pathology and translational medicine, 52(5), 283-289 (2018-09-22)
Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become
Helene Geddert et al.
Human pathology, 34(9), 850-856 (2003-10-17)
p63, a member of the p53 gene family, is known to encode functionally antagonistic protein isoforms. Although transactivating protein isoforms display p53-like functions, deltaNp63 isoforms act toward p53 in a dominant negative way. Using immunohistochemistry, we examined the expression of
Ritika Walia et al.
The Indian journal of medical research, 146(1), 42-48 (2017-11-24)
Accurate histopathological subtyping of non-small cell lung carcinoma (NSCLC) is essential for targeted therapeutic agents. Immunohistochemistry (IHC) is helpful in identification of different tumour subtypes. In this study two marker approaches, one each for glandular and squamous cell differentiation was

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