추천 제품
생물학적 소스
mouse
Quality Level
100
500
결합
unconjugated
항체 형태
culture supernatant
항체 생산 유형
primary antibodies
클론
6F-H2, monoclonal
설명
For In Vitro Diagnostic Use in Select Regions (See Chart)
형태
buffered aqueous solution
종 반응성
human
포장
vial of 0.1 mL concentrate (348M-94)
vial of 0.5 mL concentrate (348M-95)
bottle of 1.0 mL predilute (348M-97)
vial of 1.0 mL concentrate (348M-96)
bottle of 7.0 mL predilute (348M-98)
제조업체/상표
Cell Marque™
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
동형
IgG1κ
제어
kidney, mesothelioma, ovarian carcinoma (serous), testis
배송 상태
wet ice
저장 온도
2-8°C
시각화
nuclear
유전자 정보
human ... WT1(7490)
일반 설명
Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed intissues of mesodermal origin. The Wilms’ tumor gene encodes a protein that functionsas a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma and thus isused as a marker for these neoplasms.
품질
 IVD |  IVD |  IVD |  RUO |
결합
WT-1 Positive Control Slides, Product No. 348S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
물리적 형태
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
제조 메모
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
기타 정보
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
법적 정보
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Alberto M Marchevsky
Archives of pathology & laboratory medicine, 132(3), 397-401 (2008-03-06)
The diagnosis of malignant mesothelioma (MM) is rendered with the aid of immunohistochemistry to demonstrate the presence of "mesothelial," "epithelial," or "sarcomatous" differentiation. Antibody panels that have been proposed for the distinction between MM and other neoplasms usually include 2
Nelson G Ordóñez
Archives of pathology & laboratory medicine, 129(11), 1407-1414 (2005-10-29)
Several new immunohistochemical markers that can assist in the diagnosis of mesotheliomas have been recognized recently. This article reviews the current information available on these markers and also provides a practical approach to the immunohistochemical diagnosis of epithelioid mesotheliomas. Current
R Barnoud et al.
The American journal of surgical pathology, 24(6), 830-836 (2000-06-08)
Desmoplastic small round cell tumors (DSRCTs) present a reciprocal chromosomal translocation, t(11;22)(p13;q12), that results in fusion of Ewing's sarcoma and Wilms' tumor (WT1) genes. The authors evaluated 15 DSRCTs and 71 other tumors often considered in the differential diagnosis for
Hadi Yaziji et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(4), 514-523 (2006-03-24)
We evaluated the sensitivity and specificity of 10 monoclonal and two polyclonal antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma (AdCA) using immunohistochemistry (IHC). The antibodies were directed against the mesothelial-associated antigens mesothelin, calretinin, cytokeratin 5, thrombomodulin, Wilms' tumor-1 (WT-1) gene
Koji Tsuta et al.
Applied immunohistochemistry & molecular morphology : AIMM, 17(2), 126-130 (2009-06-12)
Malignant pleural mesothelioma (MPM) is known to mimic the morphology of a number of diverse neoplastic conditions. WT-1 protein is conventionally used as a positive mesothelioma marker. Recently, a new monoclonal antibody clone WT49 has recently become commercially available. To
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