311R-1

PAX-2 (EP235) Rabbit Monoclonal Primary Antibody

• UNSPSC 코드: 12352200
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100; 500
• 결합: unconjugated
• 항체 형태: culture supernatant
• 항체 생산 유형: primary antibodies
• 클론: EP235, monoclonal
• 설명: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 형태: buffered aqueous solution
• 종 반응성: human
• 포장: bottle of 1.0 mL predilute (311R-17); bottle of 7.0 mL predilute (311R-18); vial of 0.1 mL concentrate (311R-14); vial of 0.5 mL concentrate (311R-15); vial of 1.0 mL concentrate (311R-16)
• 제조업체/상표: Cell Marque^™
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• 동형: IgG
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 유전자 정보: human ... PAX2(5076)

설명

일반 설명

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.¹ Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.² More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).³

품질

IVD

IVD

IVD

RUO

결합

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

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기타 정보

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법적 정보

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