309M-1

Oct-4 (MRQ-10) Mouse Monoclonal Antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100; 500
• 결합: unconjugated
• 항체 형태: diluted ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: MRQ-10, monoclonal
• 설명: For In Vitro Diagnostic Use in Select Regions (See Chart)
• 양식: buffered aqueous solution
• 종 반응성: human
• 포장: vial of 0.1 mL concentrate (309M-14); vial of 0.5 mL concentrate (309M-15); bottle of 1.0 mL predilute (309M-17); vial of 1.0 mL concentrate (309M-16); bottle of 7.0 mL predilute (309M-18)
• 제조업체/상표: Cell Marque^™
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
• 동형: IgG
• 제어: seminoma
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 시각화: nuclear
• 유전자 정보: human ... POU5F1(5460)

설명

일반 설명

Oct-4 is a transcription factor that functions in the regulation and maintenance of pluripotency in embryonic stem and primordial germ cells. Oct-4 immunoreactivity has been demonstrated in gonadal and extra-gonadal seminomas, dysgerminomas, and embryonal carcinomas. In addition, the immunohistochemical detection of Oct-4 assists in the evaluation of intratubular germ cell neoplasia (IGCN).

Oct-4 is a transcription factor that maintains and regulates pluripotency in embryonic stem and germ cells. Anti-Oct-4 has shown a very high sensitivity and specificity in seminoma/dysgerminoma, embryonal carcinoma, and the germ cell component of gonadoblastoma by nuclear immunostaining. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma). In one study that looked at anti-Oct-4 staining in clear cell carcinomas, 4 of 14 tumors were found to be focally positive. In another study, 49 endometrioid carcinomas were Oct-4 negative. Rarely dysgerminoma may have a morphologic appearance that overlaps with sex cord-stromal tumors, especially poorly differentiated Sertoli cell tumors. In two studies however, all sex cord-stromal tumors of the testis and granulosa cell tumors of the ovary were Oct-4 negative.

품질

IVD

IVD

IVD

RUO

결합

Oct-4 Positive Control Slides, Product No. 309S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

제조 메모

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

법적 정보

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable