추천 제품
생물학적 소스
rabbit
Quality Level
100
500
결합
unconjugated
항체 형태
culture supernatant
항체 생산 유형
primary antibodies
클론
SP4, monoclonal
설명
For In Vitro Diagnostic Use in Select Regions (See Chart)
형태
buffered aqueous solution
종 반응성
human
포장
vial of 0.1 mL concentrate (241R-14)
vial of 0.5 mL concentrate (241R-15)
bottle of 1 mL predilute (241R-17)
vial of 1 mL concentrate (241R-16)
bottle of 7 mL predilute (241R-18)
제조업체/상표
Cell Marque™
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
dilution
1:100-1:500
동형
IgG
제어
mantle cell lymphoma
배송 상태
wet ice
저장 온도
2-8°C
시각화
nuclear
유전자 정보
human ... CCND1(595)
일반 설명
Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases. In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.
품질
 IVD |  IVD |  IVD |  RUO |
결합
Cyclin D1 Positive Control Slides, Product No. 241S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
물리적 형태
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
제조 메모
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
기타 정보
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
법적 정보
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Roman Kodet et al.
Virchows Archiv : an international journal of pathology, 442(6), 538-547 (2003-05-03)
Mantle cell lymphoma (MCL) is a clinicopathological entity characterized by an aggressive clinical course, morphological features, and overexpression of cyclin D1 due to juxtaposition of the bcl-1 locus (and CCND1 gene coding for the cyclin D1) to the IgH gene.
R C Hankin et al.
Archives of pathology & laboratory medicine, 123(12), 1182-1188 (1999-12-03)
This article summarizes the most useful ancillary immunohistochemical and molecular assays for use in the diagnosis of mantle cell lymphoma. The English language literature was surveyed, with an emphasis on recent publications, for articles presenting key advances in the molecular
Y Yatabe et al.
Blood, 95(7), 2253-2261 (2000-03-25)
Mantle cell lymphoma (MCL) is a distinct clinicopathologic entity of non-Hodgkin's lymphoma, characterized by a monotonous proliferation of small to medium-sized lymphocytes with co-expression of CD5 and CD20, an aggressive and incurable clinical course, and frequent t(11;14)(q13;q32) translocation. We examined
J Bartkova et al.
Cancer research, 55(4), 949-956 (1995-02-15)
D-type cyclins are proto-oncogenic cell cycle regulators implicated in the pathogenesis of several types of cancer. Amplification of the cyclin D1 gene has been described in 30-50% of human head and neck squamous cell carcinoma (HNSCC). Using immunohistochemistry on archival
J Lukas et al.
Molecular and cellular biology, 15(5), 2600-2611 (1995-05-01)
To elucidate the regulator-versus-target relationship in the cyclin D1/cdk4/retinoblastoma protein (pRB) pathway, we examined fibroblasts from RB-1 gene-deficient and RB-1 wild-type littermate mouse embryos (ME) and in human tumor cell lines that differed in the status of the RB-1 gene.
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