추천 제품
생물학적 소스
mouse
Quality Level
100
500
결합
unconjugated
항체 형태
culture supernatant
항체 생산 유형
primary antibodies
클론
LK2H10, monoclonal
설명
For In Vitro Diagnostic Use in Select Regions (See Chart)
양식
buffered aqueous solution
종 반응성
human
포장
vial of 0.1 mL concentrate (238M-94)
vial of 0.5 mL concentrate (238M-95)
bottle of 1.0 mL predilute (238M-97)
vial of 1.0 mL concentrate (238M-96)
bottle of 7.0 mL predilute (238M-98)
제조업체/상표
Cell Marque™
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
동형
IgG1κ
제어
pancreas
배송 상태
wet ice
저장 온도
2-8°C
시각화
cytoplasmic
유전자 정보
human ... CHGA(1113)
일반 설명
Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine, and parathyroid. Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
품질
 IVD |  IVD |  IVD |  RUO |
결합
Chromogranin A Positive Control Slides, Product No. 238S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
물리적 형태
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
제조 메모
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
기타 정보
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
법적 정보
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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시험 성적서(COA)
Lot/Batch Number
R Fischer-Colbrie et al.
Neuroscience, 16(3), 547-555 (1985-11-01)
Bovine chromaffin granules contain two major families of acidic proteins, chromogranins A and B. The occurrence of these proteins in endocrine and nervous tissue was investigated by immunoblotting (one- and two-dimensional), and by immunohistochemistry. Immunoblotting revealed that in anterior hypophysis
S A Hearn
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35(7), 795-801 (1987-07-01)
An antibody (LK2H10) to chromogranin A has been recommended for use in ultrastructural identification of neuroendocrine secretory granules. Previous studies have demonstrated immunoreactive chromogranin A in specimens prepared for electron microscopy by glutaraldehyde fixation only. In this study, the effect
A M Bofin et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(9), 658-664 (2003-01-17)
The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA)-positive tumour cells could be demonstrated in breast cancer cases found to be negative by conventional immunohistochemical staining. Sections
G Qvigstad et al.
The Histochemical journal, 32(9), 551-556 (2000-12-29)
Neuroendocrine cells are often disclosed in human gastric adenocarcinomas and may be recognised by their immunoreactivity towards chromogranin A. However, in dedifferentiated neuroendocrine tumour cells, the chromogranin A content may be reduced making it difficult to detect with conventional immunohistochemical
G J Kontochristopoulos et al.
Dermatology (Basel, Switzerland), 201(2), 123-126 (2000-10-29)
Although Merkel cell carcinoma (MCC) exhibits specific clinical and histologic features, differentiation from other cutaneous neoplasms, such as lymphoma, metastatic oat cell carcinoma and malignant melanoma (MM), may sometimes be difficult. The aim of our study was to immunohistochemically differentiate
문서
Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.
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