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Merck
모든 사진(3)

주요 문서

F6377

Sigma-Aldrich

Fluorescein sodium salt

Powder

동의어(들):

Acid Yellow 73, D&C;Yellow No. 8, NaFl, NaFluo, Sodium fluorescein, Uranine

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About This Item

실험식(Hill 표기법):
C20H10Na2O5
CAS Number:
Molecular Weight:
376.27
색상 지수 번호:
45350
Beilstein:
3833041
EC Number:
MDL number:
UNSPSC 코드:
12171500
PubChem Substance ID:
NACRES:
NA.47

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product name

Fluorescein sodium salt, used as fluorescent tracer

Quality Level

형태

powder

기술

titration: suitable

색상

orange to brown

pH

8.3 (20 °C, 10 g/L)

mp

>300 °C

solubility

H2O: 1 mg/mL

density

0.78 g/cm3 at 29.6 °C (85.3 °F at 699.7 hPa)

형광

λex 460 nm; λem 515 nm(lit.)

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일반 설명

Fluorescein is a xanthene dye and is a common labeling agent in biology.[1]

애플리케이션

Fluorescein sodium salt has been used as a solute to study microvessel permeability.[2][3] It has been used as a test molecule to study blood barrier penetration.[4]
Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius.[5] Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models.[6][7][8] The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes.[9] Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).[10]

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

423.7 °F - Pensky-Martens closed cup

Flash Point (°C)

217.6 °C - Pensky-Martens closed cup

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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    문서 라이브러리 방문

    P Kozler et al.
    Physiological research, 52(5), 607-614 (2003-10-11)
    The aim was to study the blood-brain permeability according to the distribution in the rat brain of Evans blue (EB) and sodium fluorescein (NaFl) administered by an intracarotid injection. Eighteen animals were divided into six groups according to the state
    D Montermini et al.
    The Journal of physiology, 543(Pt 3), 959-975 (2002-09-17)
    The permeability, P(S), to sodium fluorescein (Stokes-Einstein radius = 0.45 nm) has been measured in single mesenteric capillaries of pithed frogs and anaesthetised rats as perfusion velocity, U, was varied over a range from 400 up to 2000-10,000 microm s(-1).
    R Oishi et al.
    Naunyn-Schmiedeberg's archives of pharmacology, 339(1-2), 159-165 (1989-01-01)
    Morphine (5 mg/kg, s.c.) caused a submaximal increase in the brain level of sodium fluorescein administered i.v. Histamine H1-antagonists, diphenhydramine and mepyramine, given either i.p. or i.c.v., had no significant influence on the effect of morphine. H2-Antagonists, cimetidine and ranitidine
    In vitro model of the outer blood-retina barrier.
    Steuer H
    Brain Research. Brain Research Protocols, 13, 26-26 (2004)
    Structural mechanisms of acute VEGF effect on microvessel permeability.
    American Journal of Physiology. Heart and Circulatory Physiology, 284, H2124-H2124 (2003)

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