D8064
4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt
≥95% purity (HPLC), solid
동의어(들):
Di-4-ANEPPS
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C28H36N2O3S
CAS Number:
Molecular Weight:
480.66
MDL number:
UNSPSC 코드:
12171500
PubChem Substance ID:
NACRES:
NA.47
추천 제품
![4-(2-[6-(Dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium inner salt ≥95% (HPLC), solid](/deepweb/assets/sigmaaldrich/product/structures/276/606/9b895cb0-f3b8-42d2-bceb-a788c0bcf884/640/9b895cb0-f3b8-42d2-bceb-a788c0bcf884.png)
product name
4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt, ≥95% (HPLC), solid
Quality Level
분석
≥95% (HPLC)
형태
solid
분자량
480.66
기술
titration: suitable
색상
orange to dark red
solubility
DMF: soluble
DMSO: soluble
ethanol: soluble
ε (흡광계수)
≥38000 at 493-499 nm in methanol
응용 분야
diagnostic assay manufacturing
hematology
histology
저장 온도
2-8°C
SMILES string
CCCCN(CCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1
InChI
1S/C28H36N2O3S/c1-3-5-17-30(18-6-4-2)28-13-12-26-22-25(10-11-27(26)23-28)9-8-24-14-19-29(20-15-24)16-7-21-34(31,32)33/h8-15,19-20,22-23H,3-7,16-18,21H2,1-2H3
InChI key
HAPJROQJVSPKCJ-UHFFFAOYSA-N
애플리케이션
4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt has been used as a voltage sensitive dye in cardiac cells.
생화학적/생리학적 작용
Membrane potential dye that responds to changes in membrane potential monitored by fluorescence excitation changes at 440 and 505 nm; correlated to changes in membrane potential of the cell.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Andrew D Bachtel et al.
IEEE transactions on bio-medical engineering, 58(7), 2120-2126 (2011-05-04)
We developed a new method for ratiometric optical mapping of transmembrane potential (V(m)) in cardiac preparations stained with di-4-ANEPPS. V(m)-dependent shifts of excitation and emission spectra establish two excitation bands (<481 and >481 nm) that produce fluorescence changes of opposite
P Fromherz et al.
Biochimica et biophysica acta, 1068(2), 149-156 (1991-09-30)
The voltage sensitivity of fluorescence of an aminobenzstyryl-pyridinium dye (di4-ANEPPS) is characterized in Retzius cells dissociated from the leech. The modulation of the complete spectra of excitation and emission is determined. The spectral changes induced by depolarization are described by
Engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and human embryonic stem cell-derived ventricular cardiomyocytes (hESC-VCMs).
Chen Y, et al.
Macromolecular Bioscience, 15, 426-436 (2015)
J M Davidenko et al.
Nature, 355(6358), 349-351 (1992-01-23)
Excitable media can support spiral waves rotating around an organizing centre. Spiral waves have been discovered in different types of autocatalytic chemical reactions and in biological systems. The so-called 're-entrant excitation' of myocardial cells, causing the most dangerous cardiac arrhythmias
Zachary Laksman et al.
Scientific reports, 7(1), 5268-5268 (2017-07-15)
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing. We generated atrial-like cardiomyocytes (CMs) from hESCs which preferentially expressed atrial-specific
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