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Merck
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Key Documents

A9797

Supelco

Ambroxol hydrochloride

analytical standard

동의어(들):

2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

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About This Item

실험식(Hill 표기법):
C13H18Br2N2O · HCl
CAS Number:
Molecular Weight:
414.56
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

analytical standard

Quality Level

유통기한

limited shelf life, expiry date on the label

기술

HPLC: suitable
gas chromatography (GC): suitable

응용 분야

forensics and toxicology
pharmaceutical (small molecule)
veterinary

형식

neat

저장 온도

2-8°C

SMILES string

Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2

InChI

1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

InChI key

QNVKOSLOVOTXKF-PFWPSKEQSA-N

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일반 설명

Ambroxol hydrochloride is a mucolytic expectorant and a metabolite of bromhexine. It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

애플리케이션

Ambroxol hydrochloride standard may be used as a reference standard in the determination of ambroxol hydrochloride in pharmaceutical preparations using reversed-phase sequential injection chromatography (RP-SIC) and reversed-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

생화학적/생리학적 작용

Metabolite of bromhexine.
A Nav1.8-preferring sodium channel blocker

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Concise Dictionary of Pharmacological Agents: Properties and Synonyms (2012)
Jauch, R., et al.
Arzneimittelforschung, 13, 474-474 (1963)
Wolfram Gaida et al.
Neuropharmacology, 49(8), 1220-1227 (2005-09-27)
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however, show only limited selectivity
Sequential injection chromatographic determination of ambroxol hydrochloride and doxycycline in pharmaceutical preparations.
Satinsky D, et al.
Talanta, 68(2), 214-218 (2005)
Kazufumi Honda et al.
Redox biology, 41, 101926-101926 (2021-03-23)
Chemosensitivity to cisplatin derivatives varies among individual patients with intractable malignancies including ovarian cancer, while how to unlock the resistance remain unknown. Ovarian cancer tissues were collected the debulking surgery in discovery- (n = 135) and validation- (n = 47) cohorts, to be analyzed

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