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Merck
모든 사진(2)

문서

96708

Supelco

Phosphonoacetic acid

TraceCERT®, 31P-qNMR Standard, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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About This Item

Linear Formula:
(HO)2P(O)CH2CO2H
CAS Number:
Molecular Weight:
140.03
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Quality Level

제품 라인

TraceCERT®

grade

TraceCERT®

형태

solid

유통기한

limited shelf life, expiry date on the label

제조업체/상표

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

기술

qNMR: suitable

mp

143-146 °C (lit.)

응용 분야

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical

SMILES string

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

InChI key

XUYJLQHKOGNDPB-UHFFFAOYSA-N

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일반 설명

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.


Check out our entire range of quantitative NMR standards (qNMR standards)

애플리케이션


  • Enhancing Guide RNA Stability and Editing Yields: Phosphonoacetate modifications have been shown to significantly enhance the stability and editing efficiency of guide RNAs for Cas9-based genome editors. This development has profound implications in genetic engineering and therapeutic applications, where precision and stability are crucial (Ryan et al., 2023).

  • Glomerular and Tubulointerstitial Nephropathy Study: Phosphonoacetic acid has been indirectly related to studies on kidney diseases such as glomerular and tubulointerstitial nephropathy, showcasing its potential relevance in medical research to understand and treat complex renal conditions (Pleško et al., 2021).

  • Environmental Impact of Phosphonoacetate: Research on PMIDA-modified magnetic nanoparticles, including those related to phosphonoacetate, explores their application in liver MRI, indicating its utility in enhancing diagnostic imaging techniques and its potential environmental implications (Demin et al., 2018).

  • CRISPR-Cas Specificity Improvement: Modifications including phosphonoacetate derivatives have been employed to improve the specificity and efficiency of CRISPR-Cas systems in gene editing, underscoring the chemical′s role in cutting-edge biotechnological research (Ryan et al., 2018).

  • Cardiovascular Pharmacology: Studies involving phosphonoacetic acid have been connected to cardiovascular pharmacology, particularly in exploring the mechanisms that inhibit calcification in vascular tissues, which is vital for developing treatments for vascular calcification diseases (Duan et al., 2017).

추천 제품

Check out ChemisTwin, our brand new online portal for identity confirmation of NMR spectra. A feature for quantitative NMR is in development. Learn more or reach out to us for a free trial.

법적 정보

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서

The use of CRMs for the NMR quantification of phosphorylated organic compounds and metabolites offers several advantages as it is based on a signal comparison of the analyte with an internal or external reference standard.

In certain cases, 1H qNMR reaches its limits, especially regarding the certification of complex and larger molecules. However, new fields of application often also bring along the presence of heteroatoms, namely 31P and 19F. We therefore introduced 3 CRMs for 19F qNMR with traceability to the SI.

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