901425

White-Clark catalyst

• 동의어(들): [MnIII(ClPc)]Cl
• 실험식(Hill 표기법): C₃₂Cl₁₇MnN₈
• CAS Number: 2226663-68-7
• Molecular Weight: 1154.04
• UNSPSC 코드: 12161600
• NACRES: NA.22

속성

• 형태: powder
• 반응 적합성: reaction type: Cross Couplings; reagent type: catalyst; core: manganese

설명

애플리케이션

This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF₄) or Lewis acid (BF₃), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens.

기타 정보

Manganese-catalysed benzylic C(sp³)–H amination for late-stage functionalization

법적 정보

This product is patent pending under application #62/569,872.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable