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Merck
모든 사진(1)

Key Documents

SCT038

Sigma-Aldrich

BioTracker Orange OH and HClO Dye

Live cell imaging probe to detect hydroxy radical (OH) or hypochlorous acid (HClO) in live cells.

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About This Item

UNSPSC 코드:
12352207
NACRES:
NA.47

형태

lyophilized

응용 분야

cell analysis

검출 방법

fluorometric

일반 설명

Reactive oxygen species (ROS) are important mediators in a variety of biological and pathological events. For example, ROS generated in mitochondria play important roles in the modulation of signal transduction cascades and transcription factors. However, oxidative stress due to excessive generation of ROS is implicated in many human diseases, including acute and chronic inflammatory processes, ischemic stroke, diabetes, sepsis, ischemia-reperfusion injury, atherosclerosis, and neurodegenerative disorders.BioTracker Orange OH and HClO Dye is an orange fluorescent probe to detect hydroxy radical (・OH) or hypochlorous acid (HClO) in live-cell imaging. It can detect -OH and HClO among other reactive oxygen species (O2-, H2O2, NO, ONOO-). Its nearly red fluorescence spectrum allows multicolor imaging with green (ex. GFP, FITC) and blue (ex. Hoechst 33342) fluorophores. Because of its positive charge, OxiORANGE tends to localize within mitochondria. It has high photostability and is suitable for time-lapse imaging of intracellular hROS generation.Spectral Properties:Absorbance (max): 553mEmission (max): 577nmResearch Category:Live Cell Dye

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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