추천 제품
product name
MCA205 Mouse Fibrosarcoma Cell Line, MCA205 mouse fibrosarcoma cell line is an excellent model for studying immune response to tumor cells and the development of targeted cancer immunotherapies.
생물학적 소스
mouse
기술
cell culture | mammalian: suitable
배송 상태
ambient
일반 설명
Cancer immunotherapy is a rapidly expanding field that has produced significant advances in cancer treatment. Understanding the interactions of tumor cells with the immune system is crucial to the development of effective immunotherapeutic approaches. Fibrosarcoma is a rare yet aggressive soft-tissue sarcoma characterized by frequent tumor recurrences and a high degree of resistance to radio- and chemotherapy .
MCA-205 is a weakly immunogenic fibrosarcoma-derived cell line that has been used in many studies to induce tumor-reactive T lymphocytes, the key aspect of adoptive immunotherapy . MCA-205 cells are widely utilized as stimulators for inducing cytokine expression . The MCA-205 mouse fibrosarcoma cell line is an excellent model for studying the immune responses to tumor cells and for supporting the development of targeted cancer immunotherapies.
Source:
Non-GMO. MCA-205 was derived from 3-methylcholanthrene-induced fibrosarcoma in C57BL/6 mice. Tumors were maintained in vivo by serial subcutaneous transplantation in syngeneic mice and single-cell suspensions were prepared from solid tumors by enzymatic digestion . From these cells the MCA-205 cell line was established and maintained in vitro.
Source:
Non-GMO. MCA-205 was derived from 3-methylcholanthrene-induced fibrosarcoma in C57BL/6 mice. Tumors were maintained in vivo by serial subcutaneous transplantation in syngeneic mice and single-cell suspensions were prepared from solid tumors by enzymatic digestion . From these cells the MCA-205 cell line was established and maintained in vitro.
세포주 설명
Cancer Cells
애플리케이션
MCA205 mouse fibrosarcoma cell line is an excellent model for studying immune response to tumor cells and the development of targeted cancer immunotherapies.
Research Category
Cancer
Oncology
Cancer
Oncology
This product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.
품질
• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination
저장 및 안정성
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
T Chou et al.
Journal of immunology (Baltimore, Md. : 1950), 140(7), 2453-2461 (1988-04-01)
We have previously established an in vitro sensitization (IVS) procedure with which lymphocytes from tumor-bearing mice could be expanded and sensitized to acquire antitumor reactivity capable of mediating the regression of established pulmonary metastases from the weakly immunogenic MCA 105
Fabrizio Mattei et al.
iScience, 25(10), 105110-105110 (2022-10-04)
Trogocytosis is a cellular process whereby a cell acquires a membrane fragment from a donor cell in a contact-dependent manner allowing for the transfer of surface proteins with functional integrity. It is involved in various biological processes, including cell-cell communication
Sara Andreone et al.
Cancers, 11(11) (2019-11-14)
Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responses mediated by immunotherapy with the 'alarmin' intereukin-33 (IL-33) in melanoma mouse models. Here, we analyzed
H Kagamu et al.
Cancer research, 56(19), 4338-4342 (1996-10-01)
The ability to generate a large number of tumor-reactive T lymphocytes is the most critical requirement for adoptive immunotherapy. Our laboratory has previously demonstrated that cells from tumor-draining lymph nodes (LNs) are an excellent source of tumor-reactive T lymphocytes. After
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