MABT390

Anti-Syntaxin-2 Antibody, clone 2F2.1

clone 2F2.1, from mouse

• 동의어(들): Syntaxin-2, Epimorphin
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: 2F2.1, monoclonal
• 종 반응성: human
• 기술: immunocytochemistry: suitable; western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_001971
• UniProt 수납 번호: P32856
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... STX2(2054)

설명

일반 설명

The protein named Syntaxin-2 or Epimorphin is a multifunctional membrane protein with dual topology. Its C terminus is membrane anchored. When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2. When flipped inside out the N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called Epimorphin. This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts. When expressed by mesenchymal cells it can instruct epithelial morphogenesis at epithelial mesenchymal interfaces, and Syntaxin-2 is protein that is essential for epithelial cell and tissue morphogenesis and synaptic function in nervous system communication. Syntaxin-2 interacts with synaptotagmin-6 (SYT6) and synaptotagmin-8 (SYT8) in calcium dependent exocytosis of synaptic vesicles and may mediate calcium regulation of exocytosis in the acrosomal reaction in sperm cells as well.

면역원

GST-tagged recombinant protein corresponding to human Syntaxin-2.

애플리케이션

Anti-Syntaxin-2 Antibody, clone 2F2.1 is a highly specific mouse monoclonal antibody, that targets Syntaxin 2 & has been tested in western blotting & ICC.

Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Syntaxin-2 in SH-SY5Y cells.

Research Category
Cell Structure

Research Sub Category
Cytoskeletal Signaling

품질

Evaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Syntaxin-2 in 200 µg of SH-SY5Y cell lysate.

표적 설명

~ 33 kDa observed

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable