추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
44G4, monoclonal
종 반응성
human
기술
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
동형
IgG1κ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... ENG(2022)
일반 설명
Endoglin (CD105) is a homodimeric integral membrane glycoprotein comprised of a 95 kDa subunit. Endoglin is a component of the TGF-β receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family of ligands to signaling receptors. Endoglin binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. Endoglin is also expressed by U937 cells and by activated macrophages. Endoglin expression is up-regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.
면역원
Whole HOON Pre-B Leukemic Cells
애플리케이션
Anti-Endoglin (CD105) Antibody, clone 44G4 is an antibody against Endoglin (CD105) for use in FC, IH & IP.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory to detect Endoglin in normal human lymph node, tonsil, spleen thrymus, liver, breast, lung, and kidney specimens (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to IP Endoglin from HOON, NALM-6, 3104, 3161, HL-60, U-937, EM-3 and KG-1a cells (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to IP Endoglin from HOON, NALM-6, 3104, 3161, HL-60, U-937, EM-3 and KG-1a cells (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
품질
Evaluated by Flow Cytometry in HUVEC cells.
Flow Cytometry Analysis: A 1:200 dilution of this antibody detected Endoglin in HUVEC cells.
Flow Cytometry Analysis: A 1:200 dilution of this antibody detected Endoglin in HUVEC cells.
표적 설명
71 kDa calculated
물리적 형태
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
분석 메모
Control
HUVEC cells
HUVEC cells
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
José M Díez et al.
Stem cell research & therapy, 6, 28-28 (2015-04-19)
Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FBS is desirable.
Arantxa Blázquez-Prunera et al.
Stem cell research & therapy, 8(1), 103-103 (2017-04-30)
Mesenchymal stem cells (MSCs) show promising characteristics for their use in advanced therapy medicinal products. However, there are some unresolved concerns, such as the use of animal components for their expansion. In this study we assessed the suitability of a
Qiuyun Li et al.
Molecular medicine reports, 24(3) (2021-07-24)
Hepatic ischemia/reperfusion injury (HIRI) is a complex pathophysiological process that may develop after liver transplantation and resection surgery, as well as in uncontrolled clinical conditions. Bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are potential targets for liver diseases. Thus, the present
문서
PLTMax® Human Platelet Lysate (hPL) is a superior serum-free and xeno-free media supplement alternative to fetal bovine serum (FBS) for human mesenchymal stem cell (MSC) cultures.
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