MABS2042

Anti-HPx1 Antibody, clone HIC0-3B3

clone HICO-3B3, from mouse

• 동의어(들): Human pancreas exocrine cells
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: HICO-3B3, monoclonal
• 종 반응성: human
• 포장: antibody small pack of 25 μg
• 기술: flow cytometry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable (paraffin)
• 동형: IgG1κ
• NCBI 수납 번호: NP_001493.2
• 타겟 번역 후 변형: unmodified

설명

일반 설명

Pancreas performs both the endocrine and the exocrine function. The bulk of pancreas is composed of exocrine cells that produce digestion enzymes which are released into ducts to be emptied into the duodenum. The endocrine pancreas is composed of islets of Langerhans that produce hormones. At least five distinct endocrine cell types have been identified in the endocrine pancreas, each producing a different hormone. Beta cells produce insulin, which is considered as an anabolic hormone and regulates blood glucose levels and is also involved in fat and protein synthesis. Alpha cells produce glucagon that acts when blood glucose levels are low. Ductal cells of pancreas form the epithelial lining of the branched tubes that deliver digestive enzymes into the duodenum. They also secrete bicarbonate to neutralize acidic contents coming in from stomach. Duct cells may contribute up to 10% of all pancreatic cells. Acinar cells function as a unit of the exocrine pancreas and they synthesize, store, and secrete digestive enzymes (lipase, alpha amylase, trypsin, and chymotrypsin), which under normal physiological conditions are activated only after reaching the duodenum. Premature activation of these enzymes within pancreatic acinar cells can lead to acute pancreatitis. Clone HICO-3B3 can be used to detect exocrine cells in human pancreatic tissue. (Ref.: Dorrell, C., et al. (2008). Stem Cell Research (2008). 1(3); 183-194; Grapin-Botton, A (2005). Int. J. Biochem. Cell Biol. 37(3); 504-510; Leung, PS (2006). Int. J. Biochem. Cell Biol. 38(7); 1024-1030).

특이성

Clone HICO-3B3 specifically detects human pancreas exocrine cells.

면역원

Human pancreatic enriched exocrine cells.

애플리케이션

Anti-HPx1, clone HIC0-3B3, Cat. No. MABS2042, is a mousse monoclonal antibody that detects human pancreas exocrine cells and has been tested for use in Flow Cytometry, Immunofluorescence, and Immunohistochemistry (Paraffin).

Immunofluorescence Analysis: A representative lot detected HPx1 in Immunofluorescnece applications (Dorrell, C., et. al. (2008). Stem Cell Res. 1(3):183-94).

Flow Cytometry Analysis: A representative lot detected HPx1 in Flow Cytometry applications (Dorrell, C., et. al. (2008). Stem Cell Res. 1(3):183-94; Dorrell, C., et. al. (2016). Nat Commun. 7:11756).

Research Category
Signaling

품질

Evaluated by Immunohistochemistry (Paraffin) in human pancreatic tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected HPx1 in human pancreatic tissue sections.

물리적 형태

Format: Purified

Protein G purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1